26,27 However, there was no significant interaction between type of P2Y12 inhibitors and the treatment effects of the 2 antiplatelet regimens on the major adverse cardiac and cerebrovascular events in the present study. Limitations This study has several limitations. First, the noninferiority margin ...
4,16 Patients were ineligible for enrollment if 72 hours or more had elapsed from the hospital admission for COVID-19 or SARS-CoV-2 infection confirmation, if hospital discharge was expected within 72 hours, or if they had a contraindication to P2Y12 inhibitors or a clinical requirement for ...
The question whether (and which) platelet inhibitors are able to attenuate this detrimental process is therefore highly relevant. This has been addressed in pre-clinical sepsis models as well as a few, mostly retrospective clinical studies. Some of these studies point to the direction that sepsis ...
As P2Y12 inhibitors are now used routinely in the clinic, our data suggests that this class of anti- platelet agent may be a therapeutic option to prevent tumour metastasis in specific cancers. Abbreviations CTCs: Circulating tumour cells; EMT: Epithelial-mesenchymal transition; TGF-β: ...
Pretreatment with P2Y12 inhibitors in non-ST-segment- elevation acute coronary syndrome is clinically justified. Circulation. 2014; 130(21):1891–0. 8. Montalescot G, Bolognese L, Dudek D, et al. Pretreatment with prasugrel in non-ST-segment elevation acute coronary syndromes. N Engl J Med....
As P2Y12 inhibitors are now used routinely in the clinic, our data suggests that this class of anti- platelet agent may be a therapeutic option to prevent tumour metastasis in specific cancers. Abbreviations CTCs: Circulating tumour cells; EMT: Epithelial-mesenchymal transition; TGF-β: ...
2 TAILOR PCI was designed and conducted as a pragmatic, open-label, international, multicenter, randomized clinical trial testing the hypothesis that CYP2C19 genotype–guided use of oral P2Y12 inhibitors as compared with non–genotype-guided conventional clopidogrel therapy significantly reduces ischemic ...