Ticagrelor is a potent antagonist of the P2Y12 receptor (P2Y12R) and consequently an inhibitor of platelet activity effective in the treatment of atherothrombosis. Here, we sought to further characterize its molecular mechanism of action. Initial studies showed that ticagrelor promoted a greater ...
But, the connection between the actin-mediated mechanical movement and P2YR signaling is not well proved; hence this field needs more attention to explore the molecular mechanism in AD. Similarly, the interaction of P2YR signal-mediated chemotaxis and overlapping inflammatory pathways are a point o...
Mechanism of Action Receptor Pharmacology Receptors Transport receptors Data availability No datasets were generated or analysed during the current study. Abbreviations AR-C 69931: 2-(Propylthio)adenosine-5’-O-(β,γ-difluoromethylene)triphosphate tetrasodium salt ATP: adenosine triphosphate cAMP...
In both cell lines, there was a significant increase in expression of the mesenchy- mal markers, vimentin (VIM) and plasminogen activator inhibitor-1 (PAI-1; Serpine1), while there was a signifi- cant decrease in the expression of the epithelial marker E-cadherin (CDH1) (Fig. 2b). ...
The platelet inhibitor of choice, the optimal time of initiation and the duration of treatment depend on the indication for therapy and patient characteristics. In recent years, bleeding has been identified as an important risk factor for adverse outcomes and has led to a renewed emphasis on indiv...
Selatogrel, a 2-phenylpyrimidine-4-carboxamide analog, is a potent, reversible, and selective P2Y12 inhibitor administered subcutaneously that is under development for the treatment of acute myocardial infarction (AMI) in patients with a recent history of AMI. In this review, the authors summarize...
Mazandaran University of Medical Sciences 100项与 P2Y12 receptor 相关的临床结果 2025-01-01 A Multicenter Evaluation of Clopidogrel Resistance and Its Role in Predicting Stent Thrombosis in Transcarotid Artery Revascularization Article 作者:DiLosa, Kathryn;Siada, Sammy;Kwong, Mimmie;Maximus, Steven;Wolin...
P. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21, 677–687 (2015). PubMed PubMed Central Google Scholar Lamkanfi, M. & Dixit, V. M. Mechanisms and functions of inflammasomes. Cell 157, 1013–1022 (2014). CAS PubMed Google Scholar Swanson, K...
Clopidogrel, a P2Y12 inhibitor, is a novel anti-fibrosis agent for chronic kidney disease (CKD), but its mechanisms remain unclear, which we investigated by silencing P2Y12 or treating unilateral ureteral obstruction (UUO) in LysM-Cre/Rosa Tomato mice with clopidogrel in vivo and in vitro. We...
An arterial thrombus is composed of distinct regions based on the primary mechanism of platelet activation (28). Thrombin is believed to drive platelet activation in the early phase of thrombus formation, resulting in a tightly packed core region (dark area) that limits its diffusion to the surfa...