G. Burnstock P2X ion channel receptors and inflammation Purinergic Signal, 12 (2016), pp. 59-67 CrossrefView in ScopusGoogle Scholar [35] A.C.A. Moreira-Souza, C.L.C. Almeida-da-Silva, T.P. Rangel, et al. The P2X7 receptor mediates toxoplasma gondii control in macrophages through ca...
P2X receptors contribute to many important physiological processes, including the modulation of neurotransmitter release, hearing protection, male fertility, the response to inflammation and pain sensation. They are also involved in severe disorders, such as neuropathic pain and are thus recognized as ...
breathing pattern, reinstated autonomic balance, improved cardiac function, and reduced both inflammation and biomarkers of cardiac failure. Aberrant ATP transmission in the carotid body triggers episodic discharges that via P2X3 receptors play a crucial role in the progression of heart failure and as...
Extracellular ATP, acting at P2Y and P2X receptors, has recently been shown to contribute to airway inflammation. The aim of our study was to investigate the molecular mechanisms involved in the ATP-dependent regulation of IL-8 production by airway epithelial cells. Treatment of human normal trach...
P2X receptors are widely expressed in excitatory and non-excitatory cells, such as neuron, glia, platelet, epithelia and macrophage, and participate in many important physiological and pathological processes, including synaptic transmission, pain perception, inflammation, cardio- vascular modulation, ...
P2X receptors, as ATP-gated non-selective trimeric ion channels, are permeable to Na+, K+ and Ca2+. Comparing with other ligand-gated ion channel families, P2X receptors are distinct in their unique gating properties and pathophysiological roles, and hav
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Death of murine T cells induced by extracellular ATP is mainly triggered by activation of purinergic P2X7 receptors (P2X7Rs). However, a link between P2X7Rs and pannexin1 (Panx1) channels, which are non-selective, has been recently demonstrated in other cell types. In this work, we char...
Astrocytes have been shown to respond to extracellular nucleotides via the activation of P2 receptors, either G protein-coupled P2Y receptors or P2X receptors that are ligand-gated ion channels. In this study, we have examined the manner in which activation of the P2X[sub 7] nucleotide ...