Head and neck squamous cell carcinoma (HNSCC) is the sixth leading cancer by incidence worldwide and is one of the most morbid, mortal and genetically diverse malignancies11. Despite improvements in treatment protocols, the survival rates remain disappointingly low. Insight in the molecular processes...
Approximately 12.7 million cancer cases and 7.6 million cancer deaths are estimated to occur each year worldwide1. The prevention and treatment for cancers caused increasing financial burdens around the world2. As a complex disease, cancer is strongly influenced by environmental and genetic factors...
Therefore, the cells of the P1 and P2 groups were similar to the cancer cells, whereas the cells of the P4 group might not yet have undergone the pre-malignant process. The cells in the P3 group could be transitional subpopulations that are in the process of malignant transformation. eIF4E ...
Hepatocellular carcinoma (HCC) is the sixth most common and leading cause of cancer-related death worldwide.1 Curative treatment is effective only if the cancer is diagnosed at an early stage; however, recurrence rates are high and long-term survival is poor.2 Therefore, it is imperative to ...
CDC27 in HCT116 stable cell lines led to a significant decrease in tumor weight and volume compared with the control group (n = 8, Figures 5a and b), whereas mice injected with Dcdc27 cells exhibited greater tumor growth capacity compared with the control group (n = 6, Figures 5e and ...
6a, the protein level of SOCS3 was significantly augmented in SEA-treated group compared to control group. Previous studies have also shown that SOCS3 and p53 directly interact with each other2. Therefore, we performed immunoprecipitation to determine if SOCS3 regulated LX-2 senescence triggered ...
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HCC has a high mortality rate and is the third leading cause of cancer-related deaths worldwide; it accounts for more than half a million deaths per year.1,2 Despite current developments in clinical therapies, including surgical resection, radiotherapy and chemotherapy, the high mortality rate of...