p53Rb目的 探讨p21,p27,p53和Rb蛋白表达在胃癌发生,发展中的作用.方法 应用免疫组化EnVision法检测111例胃癌,38例不典型增生,47例肠上皮化生,25例慢性萎缩性胃炎和53例正常胃黏膜组织中p21,p27,p53和Rb蛋白的表达.结果 p21和p27蛋白表达水平在不典型增生组织最高,其次是胃癌组织,与正常胃黏膜组织相比差异均有...
【题目】2019年诺贝尔生理学或医学奖授予发现细胞缺氧诱导因子HIF1α的科学家,他们的研究揭示了细胞缺氧会引发包括细胞周期改变、线粒体自噬等诸多效应,进一步研究发现高浓度ATP也会影响细胞周期(如图所示:AMPK、p21、p27、p53表示相关蛋白质)。下列叙述正确的是() ...
(P< 0.05)结论:l-1腔鳞癌患者癌组织标本的p21表达水平Lj预后呈正相天.p21有望成为13 瞵癌预后划断的候选生 物怀志物 【关键词】 口腔鳞癌;p53;p2l;p27;p16;细胞周期蛋白;预后 [中图分类号】R730.7 【文献标志码】A [文章编号】1005—4979(2011)02—0105—04 (1t'i:10.3969/j.issn.1005—4979. 20...
方法采用不同浓度的硼替佐米(0,100,200nmol/L)作用于A549细胞4h,观察其对蛋白酶体活性的影响.用硼替佐米(0,100,200nmol/L)处理A549细胞48h,采用MTT法,3H-TdR掺入法检测细胞增殖;流式细胞术PI染色检测细胞周期;Westernblot检测p21,p27表达水平的变化;连续注射观察硼替佐米对裸鼠A549细胞移植瘤体积及质量的...
AIM: The objective of this study was to evaluate the prognostic value of p21 alone and in combination with p53 or p27 for different histological subtypes of epithelial ovarian cancer and disease-free survival. PATIENTS AND METHODS: The specimens were obtained at primary surgery from a series of...
1. 2019年诺贝尔生理学或医学奖授予发现细胞缺氧诱导因子HIF1α的科学家,他们的研究揭示了细胞缺氧会引发包括细胞周期改变、线粒体自噬等诸多效应,进一步研究发现高浓度ATP也会影响细胞周期(如图所示:AMPK、p21、p27、p53表示相关蛋白质)。下列叙述不正确的是 ...
p27p53IntegrinsClara CellsCulturesNot AvailableRenald BlundellHarrison D.JBlundell R, Harrison D. Changes in the expression of p21, p27, and p53 following beta1- integrin blocking in murine Clare cells cultures. International Journal of Molecular Medicine and Advance Sciences. 2006;2:245-250....
结果90倒胃癌组织中P27唧‘、P53、P21帆阳性表达率分别为489%、567%、51I%;随肿瘤分化程度降低、浸润深度加深、恶性程度增加,P27-、P21阳性表达率逐渐降低(P<005).P53阳性表达则相反;P27删与P53、P21表达显著相关(P<005);P27删、P21～㈣表达与胃癌预后密切相关(P<0.05),P53表达与患者术后生存无显著相关(...
Although inflammatory monocytes (IM) (CD11b(+)Ly6C(hi) cells) have been shown to play important roles in cell-mediated host protection against intracellular bacteria, protozoans, and fungi, their potential impact on humoral immune responses to extracellular bacteria are unknown. IM, localized ...
SF3B4 silencing resulted in marked retardation of the A549 cell proliferation, accompanied by the accumulation of cells at the G0/G1 phase and increased expression of p27, p21, and p53. Double knockdown of SF3B4 and p53 resulted in the restoration of p21 expression and partial recovery of ...