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Phosphatidylinositol phosphates (PIPs) and cholesterol are known to regulate the function of late endosomes and lysosomes (LELs), and ORP1L specifically localizes to LELs. Here, we show in vitro that ORP1 is a PI(4,5)P2- or PI(3,4)P2-dependent cholestero
To test the PtdInsP dependency of ORP5A localization to the ER–PM junctions, structure-based point mutants R136Q and R179Q in the GFP-tagged full-length ORP5A were expressed in HeLa cells and the cellular localization was analyzed using confocal microscopy. While the wild-type (WT) GFP–...
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Full size image Discussion The major novel finding in the present study is thatP2rx7deletion led to prolonged HSPB1 induction, which facilitated astroglial autophagy via two different signaling pathways following KA injection (Fig.8). Fig. 8: Scheme of inhibitory role of P2RX7 in astroglial auto...