Nonneoplastic lesions (38.7%) comprised majority of the cases followed by benign neoplastic lesions (31.3%) and malignant neoplastic lesions (30%). Among the malignant neoplastic lesions, p63 showed positive expression in 75% (p = 0.005) and p16 showed positive expression i...
Clinical value of detection of Ki67, P16, and INp63gene expression for patients with cervical HPV positive and CIN 1. Xiangyang Traditional Chinese Medicine Hospital Affiliated to Hubei University of traditional Chinese Medicine, Xiangyang, Hubei, 441000; 2. The First People's Hospital of Xiangyang...
METHODS: Immunohistochemistry with the antibodies p16, p53, and p63 was performed in tubular, tubularvillous, and villous adenomas (n = 30) and in well, moderately, and poorly differentiated adenocarcinomas (n = 30). The p63-positive cases were submitted to double immunolabeling with the ...
andKi-67incervicalsquamousepitheliumimmaturemetaplasia(IM)andcervicalintraepithelialneoplasia(CIN).Method:86caseswithvariedcervicallesionarestudiedbyimmunohistochemicalmethod.Results:Comparewiththegroupofsquamousepithelium(n=20)whenCK17isnegative,CK17ispositiveinthegroupofcervicalimmaturemataplasia(n=26)withrateof100...
positive expression rates of p53, p16, PTEN, Ki-67 and p63 were 61.9%, 76.2%, 10.9%, 54.2%and 19.6%, respectively in EA.The expression of p53 was correlated with clinical stage, histologic classification, vascular tumor thrombus and death ( all P <0.000), and the expression of p16 was...
Both showed highly similar unfolding temperatures compared to the wild-type protein as probed by DSF, indicating that the structures and stability were not disrupted by the point mutations. Detection of fluorescence intensity upon oxidation showed similar time-dependent changes but these were positive ...
Avoid age, menopause, HPV positive, and conical surgery The effect of the method on the severity ofpostoperativepathological results.Based on the consistency of the staining results with the pathological results after surgical treatment in our hospital, the sensitivity, specificity, and accuracy of ...
usinganimmunohistochemistrytechnique.Andtheresultswereanalyzedto investigatethevalueofP16onthepredictionofprognosisofcervicalcancer.Results Ofall74cervicalcancer cases,thereare63casesshowpositiveexpressionofP16,withthepositiveexpressionrateof85%(63/74). e positiveexpressionofgeneP16isassociatedwiththeprognosisof...
Tumor cells are positive for S-100 (b), KIT (c) and keratin 903 (d), with a subset of cells staining for p63 (e; note accentuation at periphery of tumor cell nests) and calponin (f). This staining profile supports the dual ductal and myoepithelial differentiation within the tumor. ...
The molecular detection of human papillomavirus DNA as a diagnostic test to cervical carcinogenesis gave a low positive predictive value as compared to the use of biomarkers. p16INK4A and possibly p14ARF have been proposed as putative surrogate biomarkers that would allow identification of dysplastic ...