Quanterix, in association with Vrije University Amsterdam, presented a poster at AAIC 2022 that detailed the extensive validation of plasma p-tau181 as an LDT test with strong discriminatory power, on the Simoa HD-X Analyzer. They calculated a critical p-tau181 concentration cut-off level by ...
preclinical stage. In the present study, we examined the influence of plasma biomarkers on generalization performance and RAVLT delayed recall. We found negative relationships between plasma biomarkers (p-tau231 and p-tau181) and generalization performance. However, there was no relationship between pla...
Cerebrospinal fluid (CSF) p-tau181 (tau phosphorylated at threonine 181) is an established biomarker of Alzheimer’s disease (AD), reflecting abnormal tau metabolism in the brain. Here we investigate the performance of CSF p-tau217 as a biomarker of AD in comparison to p-tau181. In the Sw...
Cognition was evaluated with the Rutgers Acquired Equivalence Task (generalization task) and Rey Auditory Learning Test (RAVLT) delayed recall. MTL dynamic network connectivity was measured from functional Magnetic Resonance Imaging data. Plasma p-tau231, p-tau181, and Aβ42/Aβ40 were measured ...
B p-tau181 exhibited inferior performance than p-tau217 in the detection of Aβ + status (Area-Under the Curve [AUC]: 0.91; 0.86–0.97 for p-tau217 vs 0.72; 0.62–0.83, DeLong test p < 0.001). C Significant differences were not seen in concentrations of p-tau181 between A...
PET negativity (Extended Data Fig.2b). In a sensitivity analysis comparing alternative CSF biomarkers to determine Aβ-PET status in this uncertain group, Aβ42/Aβ40 remained as the biomarker with the highest overall accuracy compared with Aβ42 alone or p-tau181/Aβ42 (Supplementary Table3...
B Decrease in the visual acuity of P301S mice at 6 months of age (**p = 0.002; unpaired Mann– Whitney t test) and nine (**p = 0.008; unpaired Mann–Whitney t test) (WT = 15; HE = 11mice) optomotor behavioral response in P301S mice. In this test, the ...