Our purposes of this study were to evaluate the expression patterns of p- STAT3 (ser727) in cervical intraepithelial neoplasia (CIN)- and to explore its possible role in the progression of cervical cancer. Methods. Paraffin-embedded sections from 56 patients including 20 CIN 1, 10 CIN 2, ...
免疫原: Human Stat3 peptide phosphorylated at Ser 727. Complete Freund's adjuvant 用途: 科研研究 宿主: 小鼠 保质期: 科研研究 应用范围: ICFC 产地: 进口/国产 标记物: PE 包装规格: 25 tests 品牌: 齐源 抗原来源: 小鼠 适应物种: 人 克隆性: 是 标识物: 科研研究 形态: 液体 保存条...
抗体名:PathScan® Phospho-Stat3 (Ser727) Sandwich ELISA Kit 靶点:详见说明书 宿主:详见说明书 用途:公司产品仅用于科研 应用范围:公司产品仅用于科研 纯度:详见说明书 % 产地:进口、国产 品牌:谷研 货号:GOYK96862 用途:仅用于科研 亚型:IgG 是否单克隆:是 ...
Prolonged treatments with rapamycin were found to disrupt the mTORC2 assembly and to reduce the phosphorylation of STAT3 at Ser 727. Rapamycin decreased both mRNA and protein levels of MMP2 and Twist1, which are regulated by STAT3 and associated with cancer metastasis. The overexpression of STAT3...
Cell lysates were prepared and Western blot analysis was performed as previously described [19,40]. Following antibodies were used: anti-G6PD antibody (ab133525, Abcam, Cambridge, U.K.); anti-STAT3 antibody (4904, Cell Signaling Technology), anti-phospho-STAT3 antibody (Ser 727) (ab30647), ...
Transfection of Stat3S727A in murine and human breast cancer cells abolished progestin-induced in vitro and in vivo growth. Moreover, we found a positive correlation between progesterone receptor expression and nuclear localization of Stat3Ser727 phosphorylation in breast cancer biopsies. These data ...
Synthetic phospho-peptide corresponding to resides surrounding Ser727 of mouse Stat3 来源宿主 兔 反应性 经检测验证,可与人、小鼠种属来源的Phospho-Stat3蛋白 发生免疫反应. 保存建议 提供的Phospho-Stat3抗体 产品为100 ug 无色溶液,其浓度为0.5 mg/ml,溶解于包含有50%甘油, 1% BSA和0.02%硫柳汞的PBS缓冲液...
第二部分:STAT3丝氨酸727磷酸化影响新诊断幕上胶质母细胞瘤患者的预后目的:除了酪氨酸705外,STAT3丝氨酸727磷酸化(pSer727-STAT3)被认为促进肿瘤形成,并且与胶质瘤的化疗抵抗相关,但目前仍无关于其与胶质母细胞瘤(GBM)的预后的研究.本研究的目的是检测p Ser727-STAT3在GBM肿瘤组织的表达情况,深入探讨其预后价值.方法...
The major phosphorylation sites in STAT3 are Tyr 705 and Ser 727. STAT3 activation induces the various cellular signaling required for cell survival (e.g., Bcl-xl, Bcl2, c-Myc, Mcl-1 and survivin), proliferation (e.g., cyclin D1), migration and invasion (e.g., MMP-2, MMP-7, ...
STAT 3活化有两种方式,一种是JAK/STAT 3信号通路的经典活化,依赖于Tyr-705的磷酸化,另一种是依赖于Ser-727磷酸化和Lys-685乙酰化的非经典活化。STAT 3能够进入线粒体与mt DNA结合调节基因转录表达,并且能增加缺血损伤下电子传递链复合酶活性,降低ROS的产生,增加ATP的生成,减少组织损... 文档格式:PDF | ...