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Conclusion: The BRAFV600E/p-ERK/p-DRP1(Ser616) signaling pathway plays a pivotal role in glucose metabolism reprogramming, contributing to the aggressiveness and progression of BRAFV600E-positive PTC. Our findings suggest that a combined therapeutic approach using 2-DG and...
Phospho-DRP1 (Ser616) Antibody 价 格 电议 起批量 ≥1 ul 最小起订电询 供货总量电询 发货地址上海市浦东新区 建议售价￥电议/ul 更新日期 2025年02月17日 产品规格见优宁维官网 即时洽谈 立即询价 查看联系方式 收藏产品 发送留言 举报 VIP4年 上海优宁维生物科技股份有限公司 A股 企业认证:...
First, the BRAFV600E/p-ERK/p-DRP1(Ser616) signaling pathway enhances cell proliferation by upregulating hexokinase 2 expression and thereby increasing aerobic glycolysis. Second, it inhibits apoptosis by promoting mitochondrial fission and reducing ROS levels. Moreover, we demonstrated that the ...
Interestingly, we found that silencing p66Shc inhibited the activation of Drp1 that emerges as a novel contributor to mitochondrial fission in liver I/R [13, 14], as revealed by the downregulation of p-Drp1Ser616 and upregulation of p-Drp1Ser637 under liver I/R or H/R conditions (Figs....
Phospho-DRP1 (Ser616) Antibody 价格: 价格电议 产品详情:温馨提示:优宁维所有产品和服务仅用于科学研究,不用于临床应用及其他用途提供产品和服务(也不为任何个人提供产品和服务)! ... 纯度:见优宁维官网% 包装规格:见优宁维官网 用途:详见说明书 用途:详见说明书 货号:3455 品牌:CST Phospho-DRP1 (Ser637) ...
动物实验中,Mdivi-1同样能显著降低心肌梗死后梗死边缘区成纤维细胞的转化,胶原生成和纤维化的发生,改善受损的心功能.除此以外,体内和体外实验表明,心梗后梗死周边区(肌)成纤维细胞的线粒体分裂增加.Mdivi-1降低了(肌)成纤维细胞中Drp1在Ser616位点的磷酸化及线粒体分裂.此外,Mdivi-1可显著提高成纤维细胞中血红素...
Skeletal muscle pDRP1Ser616 was reduced in Ex (p<0.05) independent of PGC-1伪 and AMPK. Ex increased maximal NADH-linked OXPHOS (p<0.05) and improved succinate- and complex III-linked OXPHOS (p<0.1). Mitochondria were elongated and had reduced sphericity after Ex (p<0.001).Conclusions: ...
In addition, deactivation of ERK1/2 suppressed phosphorylation of DRP1 at Ser 616. Notably, inhibition of DRP1-dependent mitochondrial fission by Mdivi-1 inhibited KLF4 expression and transcriptional activity induced by Ang II.Conclusions: In conclusion, mitochondrial fission involves Ang II-induced VS...
Phospho-DRP1 (Ser616) Antibody价格:￥3190/次产品详情:参数规格:产品名称规格货号Phospho-DRP1 (Ser616) Antibody100 ulGOYK98170抗体的多样性:抗体的异质性。抗体的组成极为复杂,... 纯度:详见说明书% 包装规格:冻干物 用途:公司产品仅用于科研 用途:仅用于科研 ...