Righteous indignation versus misplaced frustration: P values, CIs, effect sizes and the CASTLE-AF trialcardiologyclinical trialsinternal medicineThe misplaced frustration in Sierra and colleagues' recently published letter1 left me perplexed.doi:10.1136/bmjebm-2019-111178Mayer, Martin...
Righteous indignation versus misplaced frustration: p values, CIs, effect sizes and the CASTLE-AF trial 来自 科研支点 喜欢 0 阅读量: 1 作者: Martin Mayer 关键词: cardiology clinical trials internal medicine DOI: 10.1136/bmjebm-2019-111178 ...
These estimated error rates emphasize the need to have lower P values and replicate studies that confirm the initial results before you can safely conclude that an effect exists at the population level. Additionally,studies with smaller P values have higher reproducibility rates in follow-up studies....
Instead, Greenland (Citation2019) and Amrhein, Trafimow, and Greenland (Citation2019) encourage thinking of confidence intervals as “compatibility intervals,” which use p-values to show the effect sizes that are most compatible with the data under the given model. How will accepting uncertainty...
This tortuous, technical definition for P values can make your head spin. Let’s graph it! First, we need to calculate the effect that is present in our sample. The effect is the distance between the sample value and null value: 330.6 – 260 = 70.6. Next, I’ll shade the regions o...
values toz-scores. Next, we applied a robust local weighted regression method (rlowess; ‘smooth’ function in Matlab and a span of 300) in 1,000 bootstrap subsamples of the original sample (‘bootstrp’ function in Matlab). The final model was built as the meanz-score for all values ...
The mean effect sizes between groups were significantly different if their 95% CIs did not overlap the other’s mean. To facilitate interpretation, we transformed the lnRR and its corresponding CIs back to a percentage using (\({e}^{{{\mathrm{ln}}}{RR}}-1\)) × 100%. Furthermore...
The mean effect sizes between groups were significantly different if their 95% CIs did not overlap the other’s mean. To facilitate interpretation, we transformed the lnRR and its corresponding CIs back to a percentage using (\({e}^{{{\mathrm{ln}}}{RR}}-1\)) × 100%. Furthermore...
Previous reports indicate that, although with varying effect sizes, CKD might be positively associated with plasma p-tau levels35,36,37. Indeed, we found a higher frequency of CKD in the false-positive group with the 95% Se/Sp strategy with the plasma p-tau217 (Lilly) original model (Supp...
The number of cells bearing Dcp2-GFP granules, as well as the percentage of cells presenting them, was not altered in the slt2∆ mutant when compared to the values obtained in the wild-type strain (Fig. 4b). These results support the argument that Slt2 plays a cell wall damage-...