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The ACVR1 protein belongs to the transforming growth factor-β superfamily, which comprises an extramembrane N-terminal ligand-binding domain, a transmembrane (TM) domain, an intracellular glycine–serine-rich (GS) domain, and a protein kinase (PK) domain [9–10]. ACVR1 and the type II ...
5b). Additionally, we generated an S1943A mutant (in which serine was substituted with alanine to mimic the unphosphorylated form) in a construct expressing myc-tagged MYH9. The MYH9-S1943E mutant, had a more potent capability to bind HIF-1α than the MYH9-S1943A mutant (Fig. 5d). ...
The ISR involves four serine/threonine kinases: PERK, PKR, HRI, and GCN2 [26, 27]. Among these, GCN2 can be activated by free uncharged tRNAs [28], ribosome collisions [29], or ribosome stalling [30]. Arsenic has been demonstrated to induce apoptosis in various cells through abnormal ...
government collaboration for development for Acute Radiation Syndrome (ARS), a Phase 2/3 program for hospitalized COVID-19, and a Phase 2 program in oncology; (ii) RHB-107 ( upamostat), an oral broad-acting, host-directed, serine protease inhibitor with potential for pandemic preparedness is...
et al. PEST motif serine and tyrosine phosphorylation controls vascular endothelial growth factor receptor 2 stability and downregulation. Mol. Cell Biol. 31, 2010–2025 (2011). Article CAS PubMed PubMed Central Google Scholar Duval, M., Bedard-Goulet, S., Delisle, C. & Gratton, J. P. ...
We demonstrate that the serine/threonine kinase Akt regulates cell proliferation in breast cancer cells by preventing p27[sup kip1]-mediated growth arrest... Viglietto,Giuseppe,Motti,... - 《Nature Medicine》 被引量: 971发表: 2002年 Histone deacetylase inhibitor LAQ824 down-regulates Her-2 and...
These kinases phosphorylate a couple of serine residues in the intracellular linker region of P-gp, and the PP5-PPP2R3C complex negatively regulates P-gp expression by dephosphorylating these sites29. In parallel with the current study, we examined the crosstalk between PP5-PPP2R3C and kinases...
Perforin is expressed by cytotoxic lymphocytes and released from secretory granules to form pores in target cells that allow serine protease granzymes to enter the cell and induce cell death (Metkar et al, 2002; Trapani and Smyth, 2002). Besides IFN- g expression, T-bet also controls the ...