First we analyzed STING expression in the TCGA HNSCC cohort and found that low STING mRNA is associated with worse overall survival (OS; Fig. 5a; P = 0.03). To further investigate these findings we used a second HNSCC patient cohort with primary site biopsies of oropharyngeal SCCs (n...
Furthermore, using MitoSox Red we observed that iron enhanced mROS and the mitochondria-targeted anti-oxidant SKQ1 reduced iron-induced ROS generation and cell death. Western blotting for LC3-II and P62 levels as well as immunofluorescent detection of autophagy flux with LC3B and P62 co-...