Luminal flow regulates NO and O2(−) along the nephron. Am J Physiol Ren Physiol. 2011;300:F1047–1053. CAS Google Scholar Andreoli SP, McAteer JA, Seifert SA, Kempson SA. Oxidant-induced alterations in glucose and phosphate transport in LLC-PK1 cells: mechanisms of injury. Am J ...
XO generates O2-as a secondary metabolite of purine catabolism. NOS uncoupling and subsequent O2-generation have been linked with vascular endothelial dysfunction. Although, NOS primarily produces nitric oxide (NO), it may generate O2-if it becomes uncoupled. Uncoupling of NOS is commonly seen when...