Cell HypoxiaStem Cell NicheStem CellsThe defining hallmark of stem cells is their ability to self-renew and maintain multipotency. This capacity depends on the balance of complex signals in their microenvironment. Low oxygen tensions (hypoxia) maintain undifferentiated states of embryonic, hematopoietic...
Oxygen in stem cell biology: a critical component of the stem cell niche. Cell Stem Cell. 2010;7:150–61. Article CAS PubMed Google Scholar Marxsen JH, Stengel P, Doege K, Heikkinen P, Jokilehto T, Wagner T, et al. Hypoxia-inducible factor-1 (HIF-1) promotes its degradation by ...
The relationship between stem cells and micro-environmental/culture oxygenation has been reviewed. The basic principle of stem cell biology, "the generation-age hypothesis", and hypoxic metabolic properties of stem cells are considered in the context of the oxygen-dependent evolution of life and its...
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The present invention is directed to provide cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species. To this end, provided are cancer stem cell proliferation inhibitors and inducers of intracellular accumulation of reactive oxygen species in a cancer...
With the development of rapid measurement techniques, stable oxygen isotope analysis of plant tissue is poised to become an important tool in plant physiol... Barbour,M Margaret - 《Functional Plant Biology》 被引量: 834发表: 2007年 Hydrogen isotope ratios of leaf wax n-alkanes in grasses are...
This can greatly benefit process development, as the underlying aspects of the stem cell biology are becoming further understood. Additionally, microscale strategies can also be directly employed for parameter measurement (e.g. specific cell phenotypes), ultimately leading to the development of an ...
These data show the effectiveness of a newly identified ROS inducer, which targets glutathione metabolism, in cancer treatment. 展开 关键词: cancer therapy chemical biology glutathione GST KRAS reactive oxygen species (ROS) DOI: 10.1042/BJ20140669 被引量: 9 ...
Cell Biol. 33, 8–13 (2015). Article CAS PubMed Google Scholar Winterbourn, C. C. Biological production, detection, and fate of hydrogen peroxide. Antioxid. Redox Signal. 29, 541–551 (2018). Comprehensive overview on H2O2 in biology. Article CAS PubMed Google Scholar Berridge, M. J...
The aging process on a cellular level can be treated either as the ongoing proliferation until a certain number of cell divisions is reached (the Hayflick limit) or as the aging of nondividing cells, that is, the age-related changes in cells without proliferation. The present......