Abnormal human hemoglobins (HBs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in O2 binding compared to normal human Hb. In such abnormal Hbs with mutations at position beta 99, the intersubunit hydrogen bonds ...
Hemoglobin-based oxygen carriers (HBOCs) have been studied and developed as a replacement for red blood cells (RBCs) in oxygen transport due to their similar oxygen-carrying capacities. However, applications of HBOCs are hindered by vasoactivity, oxidative toxicity, and a relatively short ...
ASchematic depiction of oxygen-augmented immunogenic PDT with C@HPOC for eliciting the anti-metastatic and abscopal effect. Human serum albumin (HSA) was hybridized with oxygen carrying hemoglobin (Hb) via intermolecular disulfide bonds to form a hybrid protein oxygen nanocarrier with Ce6 loaded (C...
Hemoglobin-based oxygen carriers have benefits, such as the lack of pathogen transmission, no need for cross-matching, and increased stability and storage time; however, compared with erythrocyte transfusions, they have a short half-life. Of various hemoglobin-based oxygen carriers, two (Polyheme ...
The elucidation of the sites at which phenylhydroxylamine was bound to hemoglobin was complicated by the lability of the bonds. When purified human ... M Kiese,T Kai - Naunyn-Schmiedeberg's archives of pharmacology 被引量: 88发表: 1976年 Method to determine the degree and stability of blood...
Compounds of the representative metals with oxygen fall into three categories: (1)oxides, containing oxide ions, O2-; (2)peroxides, containing peroxides ions,O22−,O22−,with oxygen-oxygen covalent single bonds and a very limited number ofsuperoxides, co...
Oxides, such as iron oxide or rust, form when oxygen combines with other elements. Due to its electronegativity, oxygen forms chemical bonds with almost all other elements to give corresponding oxides. The surface of most metals, such as aluminium and titanium, are oxidized in the presence of ...
Oxygen has many uses because of its ability to accept electrons from other elements to formionic bonds or to share electrons with other elements to form covalent bonds. View all Uses The most obvious use of oxygen is to support life. The process of aerobic respiration uses O2 in an ...
First, HBOCs can have a variety of structures that can be made through several fabrication methods. In addition to the polymerization method, which combines hemoglobin with various polymer materials, the cross-linking method, which strengthens the bond between hemoglobin molecules, and the encapsulation...
Furthermore, Trasatti established a correlation of log j0 values of different metals to evaluate the strength of metal−hydrogen (M−H) bonds leading to another “volcano” curve. Therefore, various transition metal-based electrocatalysts have been demonstrated with optimum M-H bond strength as ...