Abnormal human hemoglobins (HBs) with amino acid substitutions in the alpha 1 beta 2 interface have very high oxygen affinity and greatly reduced cooperativity in O2 binding compared to normal human Hb. In such abnormal Hbs with mutations at position beta 99, the intersubunit hydrogen bonds ...
摘要: The orientations of NH2 and CH3 of the title compound, C6H9NO2, are mainly stabilized by N-(HO)-O-... and C-(HO)-O-... intramolecular hydrogen bonds, as well as intermolecular N-(HO)-O-... and C-(HO)-O-... hydrogen bonds....
hemoglobin [he´mo-glo″bin] the main functional constituent of the red blood cell, serving as the oxygen-carrying protein; it is a type of hemoprotein in which each molecule is a tetramer composed of four monomers held together by weak bonds. It consists of two pairs of polypeptide cha...
Hemoglobin-based oxygen carriers are infusible oxygen-carrying fluids prepared from purified human or animal hemoglobin; they do not need to be refrigerated and cross-matching is unnecessary [1,2]. However, small amounts of residual cell membranes are very toxic. They are used as an alternative ...
The number of bonds per molecule of the hemoglobin is suitably 15-50 to such an extent as not to increase the viscosity excessively. The combination product of the hemoglobin with the inulin prolongs the half-life to twice in blood plasma in tests on rats. The results obtained by measuring ...
Compounds of the representative metals with oxygen fall into three categories: (1)oxides, containing oxide ions, O2-; (2)peroxides, containing peroxides ions,O22−,O22−,with oxygen-oxygen covalent single bonds and a very limited number ofsuperoxides, co...
5. The hemoglobin of claim 1 which is produced recombinantly. 6. A non-naturally occurring low oxygen affinity mutant hemoglobin with increased stability against autoxidation that has oxygen binding properties comparable to those of human normal adult hemoglobin in the presence of the allosteric effect...
Hemoglobin of human adults is a tetramer α2β2 consisting of four subunits, α1,α2,β1 and β2, wherein each subunit relies on intermolecular interactions such as intra-subunit hydrogen bonds to sustain its secondary and tertiary structures. Additionally, the inter-subunit hydrogen bonds formed...
Oxides, such as iron oxide or rust, form when oxygen combines with other elements. Due to its electronegativity, oxygen forms chemical bonds with almost all other elements to give corresponding oxides. The surface of most metals, such as aluminium and titanium, are oxidized in the presence of ...
Although culture systems present maximal oxygen concentrations of approximately 0.2 mmol O2 l−1, the blood of a healthy adult man can carry up to 9.5 mmol O2 L−1 due to the capacity of the blood protein hemoglobin to form four reversible bonds per molecule with oxygen (reference 23 in...