Bent end-on geometry of the iron–oxygen bond in haem proteins, as predicted by Pauling2, was first observed in the ‘picket fence’ complex3 and has since been observed in oxymyoglobin (oxyMb)4,5; in oxyerythrocruorin, however, the Fe—O—O bond is almost linear6. In oxyHb the ...
Haem is degraded to bile pigments in the catabolism of haemoproteins in mammals 1 and in the formation of photosynthetic pigments in algae 2 . The first stage of this reaction involves oxygen attack at one of the four methene-bridge carbon atoms, which is ultimately eliminated as CO(ref. 1...
Myoglobin (Mb) belongs to the family of vertebrate oxygen-binding haem proteins and is predominantly expressed in cardiac and red skeletal muscles that rely on aerobic metabolism to perform sustained work. Additional members of this protein family are of course haemoglobin, the red dye of blood, ...
These increases most likely reflect changes in the binding environment of BCT owing to the reduction of the non-haem iron. At Δt1 = 5 ms, a large positive difference density appears between BCT and D1-Y246 (Fig. 1a and Supplementary Video 1), consistent with our previous ...
In addition, all the above-mentioned duplication events appear to have resulted in a complex of multiple CydA-like proteins with the possible exception of OR-N1 and OR-N2. OR-N2 is often found in operons without another CydA-like protein (Fig. 1). H19 and heme d are found near the...
Is cooperative oxygen binding by hemoglobin really understood? Nat. Struct. Biol., 6 (1999), pp. 351-358 View in ScopusGoogle Scholar 18 M.F. Perutz Stereochemistry of cooperative effects in haemoglobin: haem–haem interaction and the problem of allostery Nature, 228 (1970), pp. 726-734 Cr...
All the examples of oncogenes analysed so far encode proteins that activate signal transduction pathways driven by protein phosphorylation. It is intriguing that in all these cases the activation of NADPH oxidases contributes to increased ROS production. Although there are other mechanisms through which...
The target proline in TaODD and its N-terminally flanking residues form a YXXLAP motif, which differs by one residue (L->Y) compared to the consensus LXXLAP prolyl-hydroxylation site(s) present in all human, and many, but not all animal, HIFα proteins.Citation16 Binding and ...
Proteins with selenocysteine, the 21st amino acid, in the primary structure. Selenomethionine can sometimes substitute for methionine during protein synthesis, but unlike selenocysteine, this is not encoded within the RNA message and is generally without functional significance.Hormesis...
Pups would likely benefit from greater iron acquisition to meet the demands of erythron expansion, production of hemoproteins, and TBO2 maturation12,36,37 as this would enhance breath-hold abilities at the initiation of independent foraging when mortality rates are generally high in pinniped pups ...