STEWART B W,NAGARAJAN S.Recombinant CD36 inhibits oxLDL-induced ICAM-1-dependent monocyted adhesion[J].Mol Immunol,2006,43:255 -267.Stewart BW, Nagarajan S. Recombinant CD36 inhibits ox- LDL-induced ICAM-1 dependent monocyte adhesion [ J ]. Mol Immunol, 2006, 43: 255-267....
动脉粥样硬化早期病变过程CD36的表达与oxLDL的摄取作用
近来,CD36也被认为是单核细胞产生的活性氮物质修饰的低密度脂蛋白(LDL)的主要受体,参与包括动脉粥样硬化(AS)在内的许多病理生理过程.该文 介绍CD36的生物学特性及其在巨噬细胞源性泡沫细胞形成和AS形成中的作用,以及CD36表达的调控机制.关键词: CD36;oxLDL;动脉粥样硬化;PPARγ;巨噬细胞 ...
Conclusions These findings suggest that oxLDL-induced NLRP3 inflammasome activation mainly depends on CD36 involved in the progression of atherosclerosis by promoting oxLDL-mediated inflammation and foam cell formation. 展开 关键词: Vascular disease oxLDL IL-1β NLRP3 inflammasome CD36 Foam cells ...
The cluster of differentiation 36 (Cd36) was identified as the most stimulated gene (Fig. 2b), which was also confirmed using additional normal and tumor tissues by qRT-PCR and western blot analysis (Fig. 2c, d). A well-known scavenger receptor, CD36 has been reported as a potential ...
CD36 is recognized as a pro-atherogenic factor, since mice lacking CD36 reveal that CD36 is a major oxLDL receptor required for the formation of foam cells [4]. Thus, understanding the regulatory mechanism of oxLDL-induced CD36 is essential and contributes by providing new targets for the ...
本文探讨CD36、粘附分子VCAM一1在oxLDL诱导的细胞粘附中的作用。方法:胶原酶消化法收获人脐静脉内皮细胞(Ec),含肝素和内皮细胞生长因子的培养液传代培养,实验采用第3—4代传代细胞。抗VIII因子相关抗体鉴定为内皮细胞。EC消化后,铺96孑L板,待贴壁、融合后,OX.LDL(50mg/L)分别与U937细胞、EC共同9阵育不同时间...
清道夫受体CD36最初被认为是一种血小板膜糖蛋白和一种血栓反应蛋白受体(TSP-1).近来,CD36也被认为是单核细胞产生的活性氮物质修饰的低密度脂蛋白(LDL)的主要受体,参与包括动脉粥样硬化(AS)在内的许多病理生理过程.该文介绍CD36的生物学特性及其在巨噬细胞源性泡沫细胞形成和AS形成中的作用,以及CD36表达的调控机...
oxLDL induces colocalization of CD36 and PAFR in lipid raft microdomains.oxLDL induces colocalization of CD36 and PAFR in lipid raft microdomains.Francisco J. O. RiosMatheus FerraciniMateus PeceninMarianna M. KogaYajuan WangDaniel F. J. KetelhuthS...
Downregulated CD36 and oxLDL uptake and stimulated ABCA1/G1 and choles- terol efflux as anti-atherosclerotic mechanisms of interleukin-10. Cardiovasc Res 2006;69:527- 535.RUBIC T,LORENZ R L. Downregulated CD36 and ox-LDL uptake and stimulated ABCA1/G1 and cholesterol efflux as anti-...