A newly-synthesised dimethylated chlorocyclodiene epoxide is metabolised by NADPH-supplemented rat liver microsomes to produee either one or both of two major metabolites. M1 and M2. Microsomes from adult male rat liver produce both metabolites. By contrast, microsomes made from the livers of ...
The reactions of these, together with those of a known 3- C-methyl epoxide ( 2), with three kinds of lithium methylcuprate were investigated. Except for 2 and 7, the vicinal monodeoxy di- C-methyl derivatives were obtained by attack of the cuprates at the sterically less-hindered site ...