Define oxidative. oxidative synonyms, oxidative pronunciation, oxidative translation, English dictionary definition of oxidative. n. 1. The combination of a substance with oxygen. 2. A reaction in which the atoms of an element lose electrons and the vale
3.2.5 Oxidized low-density lipoproteins (oxLDL) The blood transport of lipids, such as cholesterol and triglycerides, is done through the association of these lipids with proteins. This biochemical assembly makes possible the transport of hydrophobic lipids in aqueous media, such as blood plasma or...
Blood was centrifuged to separate into plasma samples, which were frozen at −80°C in a cryopreservative solution20 for later analysis for the following antioxidant parameters: (1) LDL oxidizability, indicative of susceptibility of apolipoprotein B–containing lipoproteins to oxidation as previously...
On the other hand, the abnormal lipid metabolism result in lipid accumulation in the intima, while the elevation of oxLDL can induce the activation of macrophages [246,247]. The macrophages are subsequently turned into foam cells through engulfing lipids. Then, foam cells will undergo apoptosis ...
Although it is unknown whether circulating LDL-c might represent a source of augmented urinary F2-isoprostanes, studies have demonstrated that F2-isoprostanes is formed in LDL-c when it is oxidized in vitro (31). Finally, we found that systolic blood pressure was marginally and positively ...
Macrophages scavenge oxidized-LDL (ox-LDL) forming lipid-laden foam cells11. Studies have shown that ox-LDL also induces ROS production and release of inflammatory factors, which attribute for the progression of atherosclerosis12,13. The mechanisms driving ox-LDL-induced inflammation, increased oxida...
Cytokines are tiny proteins that influence the formation of all blood cells as well as other cells that aid in the immunological and inflammatory responses of the body. In the present results, ABM elevated the inflammatory genes (TNF-α and IL-1β) and declined the anti-inflammatory genes (TG...
Venous blood from the forearm vein was collected between 7 and 9 AM following an overnight fast. The biochemical analysis was performed by a technician blind to the clinical status of the subjects. The serum lipid profiles, including triglycerides (TG), total cholesterol (TC), high-density lipo...
Bone marrow cells of apoE−/−/iNOS+/+ were transplanted into apoE−/−/ iNOS−/− mice to generate mice that lack parenchymal iNOS but express iNOS in blood cells (apoE−/−/iNOS+/+ in apoE−/−/iNOS−/−). Additionally, bone marrow cells of apoE−/−/iNOS−...
In conclusion, iron chelation therapy with deferiprone notably improved the oxidative status in thalassemia, consequently reducing the risk of oxidative-related complications. Furthermore, the improvement in red blood cell quality may improve the anemia situation in patients....