the biological sink has the potential to grow with increasing CH4concentrations. This is of particular importance as the decline of atmospheric OH, caused by reaction with atmospheric hydrogen (H2) and other gases, might accelerate
The cells' dependency on oxidizing three mitochondrial fuels (glucose, glutamine, long-chain fatty acids) was measured by determining the rate of oxidation of each fuel of cells in the presence or absence of fuel pathway inhibitors. According to the manufacturer's instructions, it was performed us...
aIntracellular ATP levels in the control andCpt1a−/−AT2 cells (n = 5 mice per group).b,cExtracellular flux analyses (b) with glucose (Glu), pyruvate (Pyr), and glutamine (Gln) in AT2 cells, and OCRs (c) are calculated (n = 9 per group; representative data of two ...
Therefore, improper control of malonyl-CoA abundance can have broad consequences for mammalian cells, due to its primary role in fatty acid anabolism and catabolism, and the ability of fatty acids to regulate membrane fluidity [21], and influence signaling pathways [22,23]. In cancer cells, ...
(ECARs) with glucose were significantly downregulated inCpt1a−/−AT2 cells (Fig.3d, e). To explore the effects of a loss of CPT1a on glycolysis further, we deletedCpt1ain the murine AT2 cell line MLE12 by CRISPR/Cas9 (clustered regularly interspaced palindromic repeats and CRISPR-...
Anabolism b. Endergonic c. Catabolism d. Redox reaction Identify the following reactions as being endergonic or exergonic. a) NAD+ accepts two electrons and a proton to become NADH b) sucrose undergoes hydrolysis to form glucose ...
To elucidate whether ACSL4-activated fatty acyl-CoA affects the decidual process through anabolism or catabolism, we observed ESC decidualization after the inhibition of β-oxidation and TAG synthesis, respectively. First, we treated ESCs with etomoxir (pharmacological inhibition of FA β-oxidation by ...
Exposure to ubiquitous endocrine-disrupting chemicals (EDCs) is a major public health concern. We analyzed the physiological impact of the EDC, di-2-ethylhexyl phthalate (DEHP), and found that its metabolite, mono-2-ethylhexyl phthalate (MEHP), had signi
even enzymes that catalyze apparently identical steps in catabolic and anabolic routes may exhibit different properties. In general, therefore, the way down (catabolism) is different from the way up (anabolism). These differences are important because they allow for theregulationof catabolic and anabol...
Body Composition and Resting Energy Expenditure in HumanAntioxidant Intake in Older Adults and Elderly PeopleAntioxidants in Health and DiseaseAppetite, Metabolism and ObesityAssessing the Mediterranean Diet in Public Health: Scoring Systems, Effects on Chronic Disease and InterventionsAssessment of Nutrient ...