Oxcarbazepine is a keto analogue of Carbamazepine and, like the parent drug, is a potent anticonvulsant used alone or in combination with other agents in the therapy of poartial seizures. Oxcarbazepine is a dibenzazepine carboxamide derivative with an anticonvulsant property. As a prodrug, oxcarbazep...
In 1990, only the first generation anti-epileptic drugs (AEDs), namely carbamazepine (CBZ), phenytoin, phenobarbital, primidone, and valproate, were commonly used for focal–onset seizures, and secondarily generalized seizures, while ethosuximide and valproate were used for generalized onset seizures...
Threshold intensity (TI) in transcranial magnetic stimulation (TMS) is decreased in both generalised and partial epilepsy. Antiepileptic drugs phenytoin, natrium valproate and carbamazepine alone or together may increase TI. Valproate and phenytoin increase cortical latencies of motor evoked potentials (...
conducted a longitudinal growth analysis to evaluate the effect of VPA, carbamazepine (CBZ), or oxcarbazepine (OXC) therapy on physical growth [9]. Of note, AEDs treatment did not affect linear growth in girls with epilepsy [9]. Taken together, findings regarding the adverse effects of AEDs ...
Skin reactions were found in 14% of the patients and in 5% of the exposures. Ninety-seven percent of the reactions occurred to either carbamazepine (CBZ, 11%), phenytoin (PHT, 8%), lamotrigine (LTG, 8%), oxcarbazepine (8%), or p 总共663名患者包括有一共2,567暴露到15不同AEDs。
The present invention provides for novel uses of the carbamazepine derivative of formula (I) and its pharmaceutically acceptable salts, in particular an improved regimen for the administration of the carbamazepine derivative of formula (I) and the pharmaceutically acceptable salts thereof for the ...
The present invention provides for novel uses of the carbamazepine derivative of formula (I) and its pharmaceutically acceptable salts, in particular an improved regiment for the administration of the carbamazepine derivative of formula (I) and the pharmaceutically acceptable salts thereof for the ...
The present invention provides for novel uses of the carbamazepine derivative of formula (I) and its pharmaceutically acceptable salts, in particular an improved regiment for the administration of the carbamazepine derivative of formula (I) and the pharmaceutically acceptable salts thereof for the ...
Research reports using animal models of ischemic insults have demonstrated that oxcarbazepine (a carbamazepine analog: one of the anticonvulsant compounds) extends neuroprotective effects against cerebral or forebrain injury induced by ischemia and reperfusion. However, research on protective effects against is...