Many long-read assemblers take the overlap-layout-consensus (OLC) paradigm, which is less sensitive to sequencing errors, heterozygosity and variability of coverage. However, current assemblers of SGS data do not sufficiently take advantage of the OLC approach.Bioinformatics...
Instead of the de Bruijn graph method, we take the overlap-layout-consensus (OLC) paradigm. The OLC is implemented by parallel computation, and has linear complexity with respect to the number of contigs. The adjacent extended contigs are merged if their alignment is confirmed by the adjusted ...
Comparison of the two major classes of assembly algorithms: overlap-layout-consensus and de-bruijn-graph. Briefings in Functional Genomics, 11(1):25-37, December 2011.Li, Zhenyu, Yanxiang Chen, Desheng Mu, Jianying Yuan, Yujian Shi, Hao Zhang, Jun Gan, et al. 2011. "Comparison of the ...
This work presents a hybrid approach on the basis of Overlap Layout Consensus for the DNA fragment assembly, where Restarting and Recentering Genetic Algorithm (RRGA) with integrated PALS is utilized as an evolutionary operator. Quality of the current proposal is quantified using overlap scores and ...