Error: Overlap matrix is not positive definite.This most likely means the basis set contains linear dependencies.Consider increasing the atomic cutoff parameter or changing the basis set.给出的建议中提到的atomic cut
In addition, the standard addition technique was applied to evaluate the performance of these methods in complex matrix. Due to the fast, simple, inexpensive, accurate, as well as without need separation steps, the proposed method can compete with high-performance liquid chromatography (HPLC). 9 ...
where causal variants were drawn from the MiXeR model, the total polygenicity in each trait is set to 0.01%, SNP heritability is set to 0.4, GWASN = 100,000. First column shows two traits where causal variants do not overlap. Second column adds a ...
BMP4 haploinsufficiency is likely to occur through nonsense-mediated RNA decay. The proband's mother (Figure 1Cvi), grandmother (Figure 1Civ), and aunt, who all have high myopia but not AM, carry the same mutation; his normal two half-brothers do not. The grandmother's refraction is ...
Error: Overlap matrix is not positive definite.This most likely means the basis set contains linear...
At the same time, we did not observe an effect of using an unbiased estimate55 of r2, thus fall back to the standard Pearson correlation coefficient. We employ small integer compression56 for efficient storage of the LD matrix. Fit procedure. We fit the model by direct optimization of ...