Error: Overlap matrix is not positive definite.This most likely means the basis set contains linear...
where causal variants were drawn from the MiXeR model, the total polygenicity in each trait is set to 0.01%, SNP heritability is set to 0.4, GWASN = 100,000. First column shows two traits where causal variants do not overlap. Second column adds a ...
BMP4 haploinsufficiency is likely to occur through nonsense-mediated RNA decay. The proband's mother (Figure 1Cvi), grandmother (Figure 1Civ), and aunt, who all have high myopia but not AM, carry the same mutation; his normal two half-brothers do not. The grandmother's refraction is ...