overexpression noun over·ex·pres·sion-rik-ˈspresh-ən :excessive expression of a gene (as that caused by increasing the frequency of transcription) We now suspect that many, if not most, can
The genetic dissection of grain yield and yield-component traits in hexaploid wheat is complicated by the compensatory effects of homoeologous genes. Their analysis in diploid model plants, such as rice, usually reveal QTLs with much higher effect sizes, e.g. 20–40% in rice vs 2–9% in he...
Inducible promoters S100a8, Cxcl1, MMP13, Saa3, IL-1b, and TNFaip6, which were selected from endogenous genes differentially regulated in the inflamed synovium of collagen-induced arthritis mice, were used to express luciferase. The constitutive PGK promoter was used to express IL-10. ...
Therefore, the identification of new deafness genes is very important because it has proven to be an excellent way to elucidate the biology and (patho)physiology of the hearing process. We performed linkage analysis on two large Belgian families 1 and 2 with non-syndromic autosomal dominant post...
Genes involved in rare mutations that completely inhibit normal ripening have been identified; such advancement is considered as a major breakthrough in determining the transcriptional control of tomato ripening [20]. These mutations includerin(ripening inhibitor),nor(non-ripening) andCnr(colourless non...
meaning that myofibers with more mitochondria (i.e., PGC-1α overexpression) may be more resistant to cell death after injury. Second, PGC-1α overexpression has been shown to enhance structure and innervation of the NMJ, in particular the pre-synaptic integrity of the NMJ4, which could part...
(AAV9) to investigate the effect of increased Rbm24 levels in adult mouse heart. Using high-resolution microarrays, we found 893 differentially expressed genes and 1102 differential splicing events in 714 genes in hearts overexpressing Rbm24. We found splicing differences in cardiac genes, such as...
meaning that myofibers with more mitochondria (i.e., PGC-1α overexpression) may be more resistant to cell death after injury. Second, PGC-1α overexpression has been shown to enhance structure and innervation of the NMJ, in particular the pre-synaptic integrity of the NMJ4, which could part...
For some years, methods of recombinant DNA technology have also been used to improve strains of coryneform bacteria producing L-amino acids by amplifying individual biosynthesis genes for L-amino acids and examining the effect on L-amino acid production. Review articles on this subject may be found...
miRNAs direct cleavage in trans of target transcripts, regulating the expression of genes involved in various regulation and development pathways (Bartel, Cell, 116:281-297 (2004); Zhang et al. Dev. Biol. 289:3-16 (2006)). miRNAs have been shown to be involved in different aspects of ...