The sights, sounds and smells of Christmas stay with many of us for a lifetime. Perhaps cinnamon in your nasal cavity automatically takes you back to Grandma’s kitchen. Or at the first glimpse of a decorated tree, you’re transported to your childhood living room. For young ones, Christma...
nasalopiateopioidspharmacokineticsLack of non-injectable naloxone formulations has impeded widespread take-home provision for the prevention of heroin/opioid overdose deaths. For non-injectable formulations that are finally being investigated, rapid onset of action and sufficient bioavailability will be vital...
Background: Postextubation high-flow nasal cannula (HFNC) is used as a support therapy in high-risk patients in ICU. This study aimed to determine the effects of HFNC therapy on lung recruitment and overdistension assessed by electrical impedance tomography (EIT). Methods: Twenty-four patients ...
We present analysis of data from a study of concentrated naloxone nasal spray formulations. Our aims are: to assess (1) pharmacokinetic properties and (2) suitability for overdose reversal in terms of naloxone absorption within 30 minutes post-dosing. Design and interventions/comparator Open-label,...
classifier was 0.93, and the coefficients of the explanatory variables were: best-corrected visual acuity (BCVA) at baseline was 0.66, BCVA at first resolution of ME was 0.51, age was 0.21, the average brightness of the ellipsoid zone (EZ) was −0.12, the intactness of the external ...
With respect to medication, the deceased patients received more antibiotics and oseltamivir than the patients who recovered. Most of the patients received corticosteroids during their hospital stays, with no difference between the groups. The deceased patients received more hydrocortisone than and two ...
The influence persists even after the post-operative period [42]. Our study, being an observational study, also provided insight into commonly employed respiratory support strategies and compared them side by side. This is, in essence, a different approach to many studies, which try to utilize ...