OVARIAN cancerMACHINE learningSUPPORT vector machinesPROGNOSISDNA repairGENE expressionBackground: Ovarian cancer (OC) is a highly heterogeneous and malignant gynecological cancer, thereby leading to poor clinical outcomes. The study aims to identify and characterize clinically relevant su...
The study aim to identify novel molecular subtypes of ovarian cancer by gene expression profiling with linkage to clinical and pathologic features. Microarray gene expression profiling was done on 285 serous and endometrioid tumors of the ovary, peritoneum, and fallopian tube. K-means clustering was ...
Given the high degree of CIN observed in HGSOC in comparison to other ovarian cancer subtypes, we next asked whether HGSOC cell lines showed higher levels of CA, and whether CA correlated with other molecular features of interest, including DNA content and the presence of micronuclei. We detect...
(OC)is a highly heterogeneous and malignant gynecological cancer, thereby leading to poor clinical outcomes.The study aims to identify and characterize clinically relevant subtypes in OC and develop a diagnosticmodel that can precisely stratify OC patients, providing more diagnostic clues for OC ...
Epithelial ovarian cancer (EOC) is a deadly disease with limited diagnostic biomarkers and therapeutic targets. Here we conduct a comprehensive proteomic profiling of ovarian tissue and plasma samples from 813 patients with different histotypes and thera
Molecular abnormalities in ovarian cancer subtypes other than high-grade serous carcinoma. Ovarian cancer is the fifth leading cause of cancer death in women in North America, and approximately two-thirds of cases of ovarian cancer are of high-gr... C Blake,Gilks - 《Journal of Oncology》 被...
Ovarian cancer (OC) is one the most life-threatening cancers affecting women’s health worldwide. Immunotherapy has become a promising treatment for a variety of cancers, but the therapeutic effects in OC remain limited. In this study, we constructed a m
In a new paper published in the journalClinical Cancer Research, CUNY SPH Associate Professor Levi Waldron and colleagues resolved the long-standing controversy over how to define molecular subtypes of high-grade serous ovarian carcinoma, the most common form of ovarian cancer and the fifth leading ...
Imaging technique allows rapid assessment of ovarian cancer subtypes and their response to treatment An MRI-based imaging technique developed at the University of Cambridge predicts the response of ovarian cancer tumors to treatment, and rapidly reveals how well treatment is working, in patient-derived...
For ovarian cancer, histopathologic types parallel endometrial cancer and include serous, mucinous, endometrioid, and clear cell; some molecular features are also shared. The most frequent type of ovarian cancer is high grade serous that often displays p53 mutation and its precursor lesions may ...