Jewish womenfamilialhereditaryincidenceriskJewish women have been reported to have a higher risk for familial breast cancer than non-Jewish women and to be more likely to carry mutations in breast cancer genes such as BRCA1. Because BRCA1 mutations also increase women's risk for ovarian cancer, ...
are Caucasian, especially of Northern European or Ashkenazi Jewish descent, are over 50 (half of all diagnosed cases are in women over 65), have a family history of breast, ovarian, endometrial (uterine), prostate, or colon cancer,
Only about 40% of the familial aggregation of breast cancer can be attributed to germline mutations in currently identified genes, primarily BRCA1 and BRCA2 . A recent genome-wide association study focusing on Jewish Ashkenazi high risk women identified a novel locus on chromosome 6 as putatively...
Germ-Line BRCA1 Mutations in Jewish and Non-Jewish Women with Early-Onset Breast Cancer BACKGROUND: Mutations in a germ-line allele of the BRCA1 gene contribute to the familial breast cancer syndrome. However, the prevalence of these mutations... MG Fitzgerald,DJ Macdonald,M Krainer,... -...
Jewish women were significantly more likely to undergo RRSO than non-Jewish women (54% v 41%, respectively; odds ratio, 1.87; 95% CI, 1.44 to 2.42). Relative risks of cancer varied by CJM, with the relative risk of breast cancer being significantly lower in 6174delT mutation carriers than...
Purpose: To compare the clinical characteristics and survival of Ashkenazi Jewish ovarian cancer patients with and without BRCA1 and BRCA2 mutations. Methods: An unselected series of 118 Ashkenazi Jewish ovarian cancer patients were screened for the three common founder mutations in BRCA1 and BRCA2....
in those <50 years of age. Other risk factors are breast and ovarian cancer on the same side of the family, Ashkenazi Jewish heritage, male breast cancer and bilateral breast cancer. The most commonly involved genes areBRCA1andBRCA2. Other rare gene mutations associated with breast cancer ...
Ethnicity: Ovarian cancer is more common among non-Hispanic white women, and those of Ashkenazi Jewish descent are at higher risk due to increased prevalence of BRCA1 and BRCA2 gene mutations. Symptoms Currently, there is no standard screening test for ovarian cancer, as the Pap test screens ...
In the US, ovarian cancer is the second most common gynecologic cancer and has the highest mortality rate of any gynecologic cancer. Incidence increases with age (peak incidence at 55–64 years of...
Ashkenazi Jewish heritage European (white) heritage: White women are much more likely to have ovarian cancer than African American women. Asbestos exposure Repeated exposure of the genitals to talc Irradiation of the pelvic area Some viruses, especially the virus that causesmumps ...