Hereditary ovarian cancer: not only BRCA 1 and 2 genes. Biomed Res Int 2015;2015:341723.Hereditary Ovarian Cancer: Not Only BRCA 1 and 2 Genes[J] . Angela Toss,Chiara Tomasello,Elisabetta Razzaboni,Giannina Contu,Giovanni Grandi,Angelo Cagnacci,Russell J. Schilder,Laura Cortesi,Stefan Rim...
In 2008, an estimated 21,650 women were diag- nosed with ovarian cancer.1 Approximately 8% to 15% of these ovarian cancers are attributable to a hereditary predisposition to breast and ovarian cancer caused by germ line mutation of the BRCA1 or BRCA2 gene.2–4 In addition, a small ...
an estimated 21,650 women were diagnosed with ovarian cancer.1Approximately 8% to 15% of these ovarian cancers are attributable to a hereditary predisposition to breast and ovarian cancer caused by germ line mutation of theBRCA1orBRCA2gene.2–4In addition, a small percentage of ovarian cancers ...
If you do not have a gene mutation, testing can be a relief if breast or ovarian cancer runs in your family. You could still develop cancer, but your risk is the same as any woman's who does not have a BRCA mutation. You may also feel relief to know that you will not pass the ...
Cancer predisposing BARD1 mutations in breast-ovarian cancer families The breast cancer susceptibility gene BARD1 (BRCA1-associated RING domain protein, MIM# 601593) acts with BRCA1 in DNA double-strand break (DSB) repair and... M Ratajska,E Antoszewska,A Piskorz,... - 《Breast Cancer Resea...
ovarian cancerDNA repairpathologytriple negativetargeted therapyPARPcisplatinumThe discovery of the first major breast cancer susceptibility gene, BRCA1, occurred... WD Foulkes,AY Shuen - 《Journal of Pathology》 被引量: 87发表: 2013年 BRCA1 expression and improved survival in ovarian cancer patients...
Murine cytotoxic T lymphocytes (CTLs) were infected, and cellular clones... Armin,Hekele,Peter,... - 《International Journal of Cancer》 被引量: 171发表: 1996年 加载更多来源期刊 Cancer Gene Therapy 1999/11/01 研究点推荐 Ovarian cancer gene therapy BRCA1 retroviral vector ...
Ovarian cancer is an aggressive disease that is frequently detected at advanced stages and is initially very responsive to platinum-based chemotherapy. However, the majority of patients relapse following initial surgery and chemotherapy, highlighting the urgent need to develop new therapeutic strategies. ...
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer. JAMA. 2015;313(13):1347-1361.ArticlePubMedGoogle ScholarCrossref 19. Lin DYW. The robust inference for the Cox proportional hazards model. J Am Stat Assoc. 1989;84:1074-1078.Google ...
A strong candidate for the 17q-linked BRCA1 gene, which influences susceptibility to breast and ovarian cancer, has been identified by positional cloning methods. Probable predisposing mutations have been detected in five of eight kindreds presumed to segregate BRCA1 susceptibility alleles. The mutatio...