Schematic representation of mucin-16 (CA125) structure: MUC16 contains three domains: the N-terminal domain (~ 12,000 amino acids in length), tandem repeat domain which is interspersed with SEA (sea urchin sperm protein, enterokinase, and agrin) domain and the C-terminal domain. The Tandem...
Points were assigned for OC, age, race, chemotherapy, year of diagnose, summary stage, surgery, and ICD-O-3 by drawing a line upward from the corresponding values to the “points line.” The “total points” are calculated as the sum of the individual score of each of the 7 variables ...
KT and DC were supported by the NIH grant entitled ‘Screening and Risk Biomarkers for Ovarian Cancer in EPIC Specimens’ (1R01CA158119). Authors contributions KL and AH wrote the statistical analysis plan; KL performed the statistical analyses; KL, AH, and RK drafted the manuscript; RTF,...
In this study, we hypothesized that in the presence of IFNg, PARPi may induce immunogenic cell death (ICD) rather than apoptosis and promote immune-mediated tumor control. In vitro, PARPi+IFNg treatment induces hallmarks of ICD in BRCAmt ov ca; such as cell surface translocation of ...
After various indicated times, the T-cell cultures were lysed in 50 mM Hepes, 150 mM NaCl, 1% IGEPAL CA-630, 2 mM PMSF, 2 mM EDTA, 1 mM Na3VO4, 50 mM NaF, and 10 mM Na4O7P2× 10 H2O for 15 min, and protein lysates were subjected to immunoblotting ...
CA-125>35 U/ml XII. Management: General Monitor intermediate lesions (not clearly benign, but not clearly suspicious) Transvaginal Ultrasoundrepeated in 6-12 weeks Some lesions may be monitored less frequently, up to one year (e.g. endometrioma,Cystic Teratoma) ...
A great deal of studies have shown that the tumor microenvironment is crucial to the occurrence and development of tumors.Citation25–27These studies enlighten us that we should not be limited to the application of traditional tumor markers (such as CA125, HE4, CEA, etc.) to judge the progre...
Ovarian cancer (ICD-10 C56) describes several related diseases with different cellular origins and molecular characteristics (Kobel et al, 2008). The majority of high-grade serous cancers, the most common and aggressive histological subtype, originate in the distal fallopian tube (Lee et al, 2007...
In-vitro-induced CD103C DCs (iCD103C DCs) were gener- ated as previously described with modifications.32 Briefly, BM was isolated from the femur and tibia of C57BL/6Ncrl mice and passed through a 70 micron screen, followed by washing and ACK lysis. Retrieved cells were resuspended at 1.5...
Since MICU1 and MICU2 has been reported to play opposing roles in MCU mMUteIiCdliizUaitn2egdhGa[dCCaaaM2nþyP]e2mf-fmeucttpptoarnkoebc3ies8,p, wlwaeteidnew-tiaennrdmtueicdneedtdoincihcnraveneasgsteeisgiainnte[[CCwaah22eþþth]]memr. in response to cisplatin in MICU2 silenced sh...