OVA peptide-pulsed DC caused the specific T cells to produce IL-2 in vivo, proliferate, and differentiate into effector cells capable of causing a delayed-type hypersensitivity reaction. By 48 hours after injection, OVA peptide-pulsed, but not unpulsed DC disappeared from the lymph nodes of ...
树突状细胞(dendriticcells,DC)在诱导和调节机体的获得性 免疫和天然免疫中发挥了重要作用,因此肿瘤疫苗能否有效的活化 DC是决定疫苗免疫效果的关键。DC能通过其模式识别受体 (patternrecognitionreceptors,PPRs)识别病原相关模式分子而活化 成熟,从而诱导天然免疫和调节获得性免疫。Toll样受体(tolllike ...