Outer membrane vesicles (OMVs) are spontaneously released by many gram-negative bacteria during their growth and constitute an important virulence factor for bacteria, helping them to survive through harsh environmental conditions. Native OMVs, naturally-released from bacteria, are produced at a level to...
Among EVs, bacterial outer membrane vesicles (OMVs) recently have gained the interest in vaccine development and targeted drug delivery. In this review, we summarize the current discoveries of OMVs and their functions. In particular, we focus on the biogenesis of OMVs and their functions in ...
In numerous studies, bacterial outer membrane vesicles (OMVs) have proved attractive as vaccine platform for homologous bacterial strains, but also as antigen delivery platform for heterologous antigens of nonbacterial diseases, including viruses, parasites, and cancer. Their application has also been ...
- 《Clinical & Vaccine Immunology Cvi》 被引量: 90发表: 2009年 Quantitative Proteomics Reveals Distinct Differences in the Protein Content of Outer Membrane Vesicle Vaccines At present, only vaccines containing outer membrane vesicles (OMV) have successfully stopped Neisseria meningitidis serogroup B ...
Gerritzen MJH, Martens DE, Wijffels RH, van der Pol L, Stork M. 2017. Bioengineering bacterial outer membrane vesicles as vaccine platform. Biotechnol Adv 35:565-574. https://doi.org/10.1016/j.biotechadv.2017 .05.003.Gerritzen, M.J.H.; Martens, D.E.; Wijffels, R.H.; van der Pol,...
Further improvement can facilitate the development of OMVs as platform vaccine product for multiple applications. Outer membrane vesicles (OMVs) are released spontaneously during growth by many Gram‐negative bacteria. They present a range of surface antigens in a native conformation and have natural ...
The stability during storage of outer membrane vesicles (OMVs) of Neisseria meningitidis group B was studied. Three types of OMVs were compared for their s... C Arigita,W Jiskoot,J Westdijk,... - 《Vaccine》 被引量: 72发表: 2004年 Next-generation outer membrane vesicle vaccines against Ne...
Brief illustration about interactions involved in OMVs and main immune cells. Legend section: stress; bacterium; outer membrane vesicles; neutrophils; dendritic cells; chemokines; cytokines; antibody Full size image OMVs with neutrophils Although OMVs are considered as non-duplicate, inanimate form nano ...
The complex gastrointestinal environment and the intestinal epithelial barrier constrain the design and effectiveness of orally administered tumour vaccines. Here we show that outer membrane vesicles (OMVs) fused to a tumour antigen and produced in the i
The abbreviations used are: OMV, Outer Membrane Vesicles; aP, acellular pertussis vaccine; wP, whole-cell pertussis vaccine; 69K, Pertactin; FHA, Filamentous Hemagglutinin; IPTG, isopropyl β-d-1-thiogalactopyranoside; CDS, Coding DNA Sequence; LB, Luria Bertani broth; HLB, Hydrophilic-Lipophilic...