Gene ID: 5015 种属 Homo sapiens 基因DNA序列编号: NM_021728.4 基因DNA描述 Homo sapiens orthodenticle homeobox 2 (OTX2), transcript variant 1, mRNA DNA编码区: atgatgtcttatcttaagcaaccgccttacgcagtcaatgggctgagtctgaccacttcg ggtatggacttgctgcacccctccgtgggctacccggggccctgggcttcttgtcccgca gccaccccccgg...
Infecting RPE cells with an AAV encoding OTX2 in-vitro, can prevent gene expression change associated to dedifferentiation of RPE cells. We identified some of these genes as direct targets of the transcription factor OTX2. Transplantation of Otx2-genetically modified RPE cells in the RCS eye ...
Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow photoreceptor degeneration. PLoS One 5, e11673.Béby F, Housset M, Fossat N, Le Greneur C, Flamant F, Godement P, et al. (2010) Otx2 gene deletion in adult mouse retina induces rapid RPE dystrophy and slow...
The orthodenticle homeobox 2, encoded by OTX2 gene, is a key transcription factor in developmental processes. In particular, it is required for the early specification of the brain and the embryonic development of sensory organs, including the, pineal gland, pituitary gland, inner part of the ...
Regeneration and neogenesis of retinal visual cell with the Otx2 gene The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is use...
14 Complete ablation of the Otx2 gene in mice is lethal, and even a heterozygous genotype can lead to loss or malformations of the brain or head.14 Later in development, OTX2 forms sensory organs and the pituitary and pineal glands. Consequently, OTX2 mutations are associated with eye ...
Regeneration and neogenesis of retinal visual cell otx2 gene The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an...
Gene ID (NCBI) 5015 Alternative Names CPHD6;MCOPS5 Application Notes: The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user. WB 1:500 - 1:2000 Western blot analysis of extracts of various cell lines, using OTX2 antibo...
Regeneration and neogenesis of retinal visual cell otx2 gene The present invention provides a medicine, comprising (a) an Otx2 protein or its partial peptide, or a salt thereof, or (b) a DNA or an RNA encoding an Otx2 protein or its partial peptide. The present medicine is useful as an...
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. A similar protein in mice is required for proper forebrain development.Tissue specificity...