Genetic Determinants of Long-Term Changes in Blood Lipid Concentrations:. Recent genome-wide meta-analyses identified 157 loci associated with cross-sectional lipid traits. Here we tested whether these loci associate (singly and in trait-specific genetic risk scores [GRS]) with longitudinal changes in...
Long-term normothermic liver perfusiondoi:10.1038/s41575-023-00850-8Eleni KotsilitiNature Reviews Gastroenterology & HepatologyNature Publishing Group UKNature Reviews Gastroenterology & Hepatology
Lactobionate and raffinose that are contained in both the UW and UM-III solutions were thought to be essential constituents for long-term preservation of liver grafts. The study not only establishes, under controlled circumstances, the superiority of the UW solution, but it also provides insight ...
Long-term alcohol ingestion leads to myelosuppression with a slight reduction in all cell lines; thrombocytopenia is common. Blood loss from the gastrointestinal (GI) tract and nutritional deficiencies producing anemia are common in alcohol withdrawal. Many patients have dehydration, and hemoconcentration...
Exposure to ionizing radiation has well-documented long-term effects on cancer rates and other health outcomes in humans. While in vitro experimental studies had demonstrated that the nature of some radiation effects depend on both total dose of the radiation and the dose rate (i.e., the patter...
Correlation of IIV on CLtAB and V1tAB as a covariance term was also included in the model. Typical parameter estimates based on the final tAB PopPK model were in good agreement with the median pharmacokinetic parameters based on bootstrap analysis (Table 3). Typical parameter estimates for CL...
Short-term graft function was evaluated during ex-vivo sanguineous reperfusion. A drawback of the use of NMP for organ preservation is the complexity of the device required as opposed to SCS. This could be overcome by combining an initial period of SCS during transportation, with NMP once the...
et al. Long-term therapeutic silencing of miR-33 increases circulating triglyceride levels and hepatic lipid accumulation in mice. EMBO Mol. Med. 6, 1133–1141 (2014). CAS PubMed PubMed Central Google Scholar Belgardt, B. F. et al. The microRNA-200 family regulates pancreatic beta cell...
Secondary Neoplasia (SN) after HCT belong to the most feared long-term complications. They include any malignant disorder occurring after HCT. There are three types of SN: therapy-related myeloid neoplasms, occurring mainly after auto-HCT; donor-derived malignancies after allo-HCT; and second solid...
Long-term shedding of infectious Epstein-Barr virus after infectious mononucleosis. J Infect Dis. 2005;191:985–9. Article PubMed Google Scholar Faulkner GC, Burrows SR, Khanna R, Moss DJ, Bird AG, Crawford DH. X-linked agammaglobulinemia patients are not infected with Epstein-Barr virus:...