这些小鼠在I-A的背景下对鸡卵清蛋白323-339肽具有特异性,这使得CD4+T细胞主要识别MHC II类分子呈递的卵清蛋白肽残基323-339。在这些小鼠中,CD4+与CD8+外周T细胞比率增加了四倍,而淋巴结T细胞则表现出对特定卵清蛋白肽(OVA323-339)的免疫反应动力学。通过直接给予卵清蛋白,可以研究这些转基因小鼠的免疫反应。这些...
OT-II和OT-I小鼠都是T细胞受体(TCR)转基因鼠。OT-II小鼠的CD4 T细胞可以识别OVA抗原(OVA-323-339),而OT-I小鼠的CD8 T细胞可以识别OVA抗原(OVA-257-264)。这些小鼠常被用作研究免疫反应和疫苗的模型。OT-II:(CD4+---ovalbumin 323-339 )These transgenic mice express the mouse alpha-chai...
Ovalbumin 是一个蛋白,简称OVA,卵清蛋白。因此,当OVA注射给小鼠会引发免疫反应。OT-1小鼠是体内CD8+T特异性识别OVAOT-11小鼠是体内CD4+T特异性识别OVA表达OVA的肿瘤打给小鼠,再给小鼠OT-1的CD8+T,相当于给小鼠肿瘤特异性T细胞。 原文:OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic ...
在这些小鼠中,CD4+与CD8+外周T细胞比例增加了四倍,淋巴结T细胞对特定卵清蛋白肽段(OVA323-339)表现出剂量依赖性的增殖反应。通过直接给予卵清蛋白,可以研究免疫反应动态。这些转基因小鼠对于研究体内T细胞生物学非常有用,如T细胞抗原受体(T cell receptor,TCR)-配体相互作用、T细胞激活、胸腺选择、抗原的交叉呈递以及...
2楼:Originally posted by梦里随想at 2015-06-13 18:51:47 OT-II小鼠纯合的小鼠上是OVA特异性的,...
OVA specific OT-II CD4+Tcells showed reduced cytokine production and lung infiltration in OVA immunized mice.M. Akirav, EitanHenegariu, OctavianPrestonHurlburt, PaulaMarie Schmidt, AnnClynes, RaphaelC. Herold, Kevan
Proliferation and activation of OVA-specific T cells cocultured with splenic APCs isolated from mated or pseudopregnant female mice after blockade of CD80 and CD86. (a) Proliferation estimated by BrdU incorporation and ELISA. Data were presented as percentages of absorbance for blocked molecules in ...
MN Kopylovich,AM Kirillov,EA Tronova,M Haukka,AJL Pombeiro 摘要: A series of cationic (2+) [Ni{HN=C(R)NHC(R)=NH}2](X)2 {R = 4-(Cl)C6H4 (1), 3-(NC)C6H4 (3), 4-(NC)C6H4 (4) and Me (7); X = Cl– (1, 3, 4) or MeCOO–·H2O (7)} and neutral [Ni{HN=...
V aplikácii Prepojenie s telefónom prejdite na položku Nastavenia a potom v rozbaľovacom zozname Zariadenia vyberte nové zariadenie. Môžem aplikáciu Prepojenie s telefónom používať s viacerými počítačmi? Áno, svoje zariadenie môžete pripojiť ...
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