OT-II和OT-I小鼠都是T细胞受体（TCR）转基因鼠。OT-II小鼠的CD4 T细胞可以识别OVA抗原（OVA-323-339），而OT-I小鼠的CD8 T细胞可以识别OVA抗原（OVA-257-264）。这些小鼠常被用作研究免疫反应和疫苗的模型。
这些小鼠携带了小鼠Tcra-V2和Tcrb-V5基因的转基因插入。这些转基因T细胞受体被设计用来识别在H2Kb(与CD8共受体通过MHC类I分子进行相互作用)背景下的卵清蛋白肽段257-264(OVA257-264)。这导致MHC类I限制性的、卵清蛋白特异性的、CD8+ T细胞(OT-I细胞)的产生。也就是说,这种小鼠的CD8 T细胞主要在MHC I分子的...
OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the ...
从第6天开始使用S1P1R拮抗剂FTY720治疗的肿瘤小鼠,防止新激活的效应细胞CD8 + T细胞从淋巴结(LN)流出并进入肿瘤,在后续时间点(第11天)分析时,肿瘤内TIM-3+ CD8+ T细胞的发展并未受到抑制(图F)。从第6天开始使用FTY720治疗的小鼠在肿瘤内显示出明显的CD8 + T细胞扩增(图G)(尽管其数量增加的幅度不及未经处理...
of CD8+ T cells to antigen.Like most TCR transgenics,these mice are somewhat immunodeficient.
These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes.The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen.Li...
OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and...
OT-I: (CD8+---ovalbumin 257-264 )These mice contain transgenic inserts for mouse Tcra-V2 and...