These mice contain transgenic inserts for mouse Tcra-V2 and Tcrb-V5 genes. The transgenic T cell receptor was designed to recognize ovalbumin peptide residues 257-264 (OVA257-264) in the context of H2Kb (CD8 co-receptor interaction with MHC class I). This results in MHC class I-restricted...
OT-II和OT-I小鼠都是T细胞受体（TCR）转基因鼠。OT-II小鼠的CD4 T细胞可以识别OVA抗原（OVA-323-339），而OT-I小鼠的CD8 T细胞可以识别OVA抗原（OVA-257-264）。这些小鼠常被用作研究免疫反应和疫苗的模型。OT-II:(CD4+---ovalbumin 323-339 )These transgenic mice express the mouse alpha-c...
The transgenic T cell receptor was designed to recognize ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in positive selection and the response of CD8+ T cells to antigen. Like most TCR transgenics, these mice are somewhat immunodeficient.我来回答 ...
Mice were immunized with OVA peptide plus LPS, and monitored for urine glucose. We also examined OT-I cell numbers in the pancreatic draining lymph node and in the pancreas 72hr post-immunization. We found that in the absence of ITK, OT-I cells were impaired in their ability to induce ...
ovalbumin residues 257-264 in the context of H2Kb and used to study the role of peptides in ...
Development of peptide-selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway Fetal thymic organ culture of TCR transgenic (Tg) tissue has been used to study issues of timing and specificity in T cell development. Because most TCR Tg... KA Hogquist,JL Bonnevie...
Direct interaction between auto-reactive CTL and specific peptide–MHC class I complexes on pancreatic beta cells is critical in mediating beta cell destruction in type I diabetes. We used mice with genetic modifications in three major pathways used by CTL, perforin, Fas and pro-inflammatory cytokin...
Expert Opinion on Biological Therapyis a medical journal covering research on all aspects of biological therapy, including gene therapy and gene transfer technologies, therapeutic peptides and proteins, vaccines and antibodies,...
Si nce that synt het ic peptide i s simi lar t o ones sec reted by ce rtain s t rains o f en te ric ba c te ria , we ques t ione d whethe r o the r ba c te r ia l pr oduc ts a l so tri gg e r th e release of that immunog lobu lin f rom phagocy tes ...
什么是OT-II和OT-I小鼠?OT-II: (CD4+---ovalbumin 323-339 )These transgenic mice express the ...