but also to a 28% decrease in deaths from any cause.10 Zoledronic acid has been linked to cases of renal insuffi- ciency, and the product labeling cur- rently includes a caution about using this agent in patients with established kidney dysfunction, but the FDA has not required additional ...
Considering a prevalence of 10.3% in this population, a recent study calculates that more than 10 million adults over 50-years-old have this condition in the U.S. There is an even higher prevalence of adults with low bone mass, affecting near 44% of the older adult population (2). ...
Bone loss and fracture are serious sequelae of kidney transplantation, associated with morbidity, mortality and high economic costs. The pathogenesis of po
Ostrowska Z, Kos-Kudla B, Swietochowska E, Marek B, Kajdaniuk D, Ciesielska-Kopacz N (2001) Influence of pinealectomy and long-term melatonin administration on GH-IGF-I axis function in male rats. Neuro Endocrinol Lett 22:255–62 PubMed CAS Google Scholar Bell NH (2001) Advances ...
[5] Estrogen plays a vital role in regulating bone metabolism, and its defi- ciency causes post-menopausal osteoporosis.[6] Insufficient serum levels of 25-hydroxyvitamin D is also a risk factor for osteoporosis and osteoporotic fractures.[10] The combination of vita- min D a...
ciency probably account for the majority of patients with postmenopausal osteoporosis. Nevertheless, all postmenopausal patients with osteoporosis should be evaluated for secondary causes of bone loss, such as long-term (more than three months) administration of systemic glucocorticoids, including high dos...
The cells were seeded in 96-well plates. After cultured for 24 hours, the cells were treated with or without 10−6 M dexamethasone, with or without resveratrol, with or without NAM. Then we added 10 mM BrdU solution into the culture medium, and further incubated for 2.5 hours....
Our previous study showed that Cxcl9 secreted by osteoblasts also attenuates type H vessels formation in bone.7 However, the effects of Cxcl9 on osteoclast bone resorption and bone loss associated with estrogen defi- ciency have not been illustrated. In this study, we found that chemokine Cxcl...
The mechanism of osteoporosis in combination with DM1 is clear, and researchers generally believe that insulin defi- ciency interferes with bone formation and mineralization and accelerates bone resorption. At the same time, most DM1 patients develop in adolescence, with incomplete bone mineralization ...
Tang J, Nuccie BL, Ritterman I,et al.:TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors.J Immunol1997,159:117–125. PubMedCASGoogle Scholar Dubinett SM, Huang M, Dhanani S,et al.:Down-regulation of murine fibrosarcoma transforming growth...