Osteogenesis imperfecta (OI) is a genetic connective tissue disorder, with the characteristic symptoms of bone fragility, recurrent fractures, impaired growth, and resulting short stature [1]. Affected individuals may also present with blue sclera, joint laxity, and dentinogenesis imperfecta (DGI) [1]...
Osteogenesis imperfecta (OI) results from various gene mutations leading to defects in type I collagen, which is the major component of both bone and dentin. Yet dentinogenesis imperfecta (DI) is found only in half of the patients with OI. Here we document patients from three families with OI...