osteogenesis imperfectasyndromeOsteogenesis imperfecta (OI), or brittle bone disease, is a heritable disorder characterized by increased bone fragility. Four different types of the disease are commonly distinguished, ranging from a mild condition (type I) to a lethal one (type II). Types III and ...
Osteogenesis imperfecta (OI), rare hereditary disease of connective tissue characterized by brittle bones that fracture easily. OI arises from a genetic defect that causes abnormal or reduced production of the protein collagen, a major component of conne
The earliest known case of osteogenesis imperfecta (OI) is in a partially mummified infant’s skeleton from ancient Egypt now housed in the British Museum in London. In 1835, Lobstein coined the term osteogenesis imperfecta and was one of the first to co
Q: WHAT IS OSTEOGENESIS IMPERFECTA? A: OI is a genetic disorder the affects the gene that produces collagen in your body. Collagen is a protein that connects tissues in your body. It also helps with the formation of teeth, ligaments, and sclera (white outer tissue of the eyeball). SYMPTOM...
Osteogenesis imperfecta (OI) is a heritable disorder characterized by low bone mass and increased bone fragility. OI presents with a broad clinical spectrum that is traditionally described by a classification combining four different types of disease severity (OI type I–IV). Recently, this classifica...
Osteogenesis imperfecta (OI) is a congenital disorder characterized by low bone mass and increased bone fragility. Four different types are commonly distinguished on the basis of clinical features and disease severity.24 Patients with OI type I have a mild phenotype with normal or near-normal height...
Osteogenesis imperfecta in childhood: impairment and disability. A prospective study with 4-year follow-up. Arch Phys Med Rehabil 2004;85(5):772-8.Engelbert RHH, Raoul HH, Frits AB, Van der Graaf Y, Helders P. Osteogenesis imperfecta in childhood: Impairment and disability- A follow-up ...
Osteogenesis imperfecta (OI) is characterized by a high fracture rate and great heterogeneity. This cross-sectional study presents skeletal investigations ... S.,Hansen,and,... - 《Bone》 被引量: 51发表: 2010年 Osteogenesis imperfecta type III and hypogonadotropic hypogonadism result in severe bon...
2.Genetic Studies of Osteogenesis Imperfecta Type Ⅰ and Two Candidate Genes of Osteoporosis;Ⅰ型成骨不全及骨质疏松症两个候选基因的遗传学研究 3.Observation on AO Calcaneal Plate in the Treatment of 18 Cases with Sanders TypesⅢ-ⅣCalcaneal FracturesSanders Ⅲ、Ⅳ型跟骨骨折18例观察 ...
Osteogenesis imperfecta (OI) is a group of inherited connective tissue disorders of varying severity characterized by bone fragility. The primary objective of this international multidisciplinary collaboration initiative was to reach a consensus for a st