3f, g). Immunohistochemical staining further indicated that UCHL1 knockout in osteoclasts led to a decrease in the expression of anabolic marker type II collagen and an increase in the expression of catabolic marker MMP13 in the knee articular cartilage of mice (Fig. 3h, i). Additionally, ...
In absence of therapies targeting symptomatic dementia, better understanding of the biology underlying a cognitive decline is warranted. Here we present the results of a meta-analysis of the impact of osteoarthritis (OA) on cognitive decline and overall mortality. Across 7 independent datasets obtained...
Here, we report a large GWA study of bone size using a simple parameter from DXA scans, the bone area. We find thirteen independent associations of common variants at twelve loci that replicate in population of European and East-Asian descent. These are the first genome wide significant loci ...