The associations of selected genetic instruments with OA and RA were estimated in UK Biobank. Diagnosed diseases status was recorded in the hospital episode statistics as the International Classification of Diseases (ICD) codes. We mapped these ICD codes to the phecode grouping system, which merges...
subchondral bone structural changes, osteophytes formation, joint inflammation, and impaired function5. Chondrocytes, the sole cell type in articular cartilage, play a crucial role in maintaining the structure and function of cartilage6. In OA, there is an imbalance in the metabolism of the cartilag...
Respondents for whom a body region (knee, hip, hand/wrist, foot/ankle) at the index date consultation could not be allocated, either through the code given or recorded in the free text of the consultation, were excluded in order to allow comparison by individual site. In order to address ...
Two hundred ten males and females aged 40 to 77 years diagnosed with degenerative hypertrophic OA of knee bone joints were assessed for eligibility, and 201 patients were enrolled in the study and included in the intention to treat (ITT) analysis. All were randomized and allocated to three stud...
All TKR cases were then verified by checking the diagnosis code to confirm that severe knee OA (ICD-9 code 715) was the reason for the surgery. We excluded all cases with any mention of diagnoses that included septic arthritis, gonarthrosis, osteomyelitis, villonodular synovitis, rheumatoid ...
To achieve this, we utilized a linked dataset of claims data and survey data. Two stratified random samples (axSpA, ICD-10 Code M45, OA of the hip, knee or polyarticular OA (ICD-10 codes M15-17)) were selected from the population of over 7 million insurants aged 18–79 who were ...