a Schematic representation of the experimental design involving intraperitoneal injection of AAV9-UCHL1 into DMM mice. b TRAP staining of the tibia subchondral bone (coronal view) 2 weeks after DMM surgery. Scale bar: 100 μm. c Quantitative analysis of TRAP-positive osteoclast density in subc...
Osteoarthritis (OA) is a degenerative joint disease that mainly involves joints of knees, hips, and hands1. OA has attracted growing public attention due to its high prevalence (over 303.1 million people are affected globally), high treatment cost2, and the lack of effective treatments3. Thus,...
principal components, and corrected for genomic control. The OA definition and related structural phenotypes were defined based on radiographs of the hip, hand and knee joints. We have used the following radiographic measurements to create (semi)-quantitative endophenotypes for the hip, knee, hand, ...
International Journal of Molecular Sciences Article Vitamin C Protects Chondrocytes against Monosodium Iodoacetate-Induced Osteoarthritis by Multiple Pathways Pu-Rong Chiu 1,2, Yu-Chen Hu 2, Tzu-Ching Huang 1,2, Bau-Shan Hsieh 2, Jou-Pei Yeh 2, Hsiao-Ling Cheng 3, Li-Wen Huang 4,*,† ...
International Journal of Molecular Sciences Article Mechanical and IL-1β Responsive miR-365 Contributes to Osteoarthritis Development by Targeting Histone Deacetylase 4 Xu Yang 1,†, Yingjie Guan 2,†, Shaoqi Tian 1, Yuanhe Wang 1, Kang Sun 1,* and Qian Chen 2 1 Department of Orthopedics...