Osteoarthritis (OA) is the most common degenerative joint disease that causes painful swelling and permanent damage to the joints in the body. The molecular mechanisms of OA are currently unknown. OA is a heterogeneous disease that affects the entire joint, and multiple tissues are altered during ...
After adjustment for age, sex, and other alleged risk factors, body mass index was found to be directly proportional to the prevalence of thumb carpometacarpal osteoarthritis in both sexes. The adjusted odds ratio was 1.29 (95% confidence interval, 1.15 to 1.43) per 5-kg/m(2) increment in...
One important characteristic of primary osteoarthritis is that the abnormalities found in the load-bearing (i.e, highly stressed) areas of the affected joint differ from those found in the non–load-bearing areas. In the load-bearing areas, radiographs can depict joint-space loss, as well as ...
the pathological signaling pathways, such as Wnt/β-catenin, NF-κB, focal adhesion, HIFs, TGFβ/ΒΜP and FGF signaling pathways, and key regulators AMPK, mTOR, and RUNX2 in the onset and development of OA. In addition, the roles of factors associated with OA, including MMPs, ADAMTS/AD...
There was increased synthesis of larger (PG) at 3, 6, and 12 weeks, and the synthesis was greater in the menisci than the articular cartilage. there was no apparent impairment of the PG ability to aggregate with hyaluronate. 展开 关键词: Animals Dogs Menisci, Tibial Osteoarthritis Disease ...
: Knee confidence as it relates to physical function outcome in persons with or at high risk of knee osteoarthritis in the osteoarthritis initiative . Arthritis Rheum , 2012, 64 : 1437–1446.Colbert CJ, Song J, Dunlop D, Chmiel JS, Hayes KW, Cahue S, Moisio KC, Chang AH, Sharma L:...
BACKGROUND: Progression of tibiofemoral (TF) and patellofemoral (PF) osteoarthritis (OA) and changes in knee function more than 15 years after anterior cruciate ligament reconstruction (ACLR) are not well understood. PURPOSE: To examine the progression of knee OA and changes in symptoms and functio...
Energy and fat intakes of children and adolescents in the united states: data from the national health and nutrition examination surveys. Dietary factors related to body weight and chronic disease risk are of interest because of recent increases in the prevalence of overweight. Secular trends... RP...
arthritis is caused. Althoughosteoarthritiscan damage any joint in the body, the disorder most commonly affects joints in the hands,knees, hips and spine. Osteoarthritis (third in the list of preference) is a leading cause of disability in the world (Craig et al., 2016). About 9.6% of men...
The field of genetics and genomics is a highly technological driven field that is advancing fast. The purpose of this year in review of genetics and genomics was to highlight the publications that apply these new technologies tools to improve understanding of the pathophysiology of osteoarthritis (...