1.The natural process of bone formation. 2. a.The hardening or calcification of soft tissue into a bonelike material. b.A mass or deposit of such material. 3. a.The process of becoming set in a rigidly conventional pattern, as of behavior, habits, or beliefs. ...
Bone - Osteogenesis, Ossification, Intramembranous: Bone is formed in the embryo in two general ways. For most bones the general shape is first laid down as a cartilage model, which is then progressively replaced by bone (endochondral bone formation). A
Thyroid Hormone in Bone and Joint Disorders J.H. Duncan Bassett, Graham R. Williams, in Genetics of Bone Biology and Skeletal Disease (Second Edition), 2018 3.2 Intramembranous and Endochondral Ossification The flat bones of the face and skull form by intramembranous ossification. Mesenchyme progenit...
There are two types of bone ossification, intramembranous and endochondral. Each of these processes begins with a mesenchymal tissue precursor, but how it transforms into bone differs. Intramembranous ossification directly converts the mesenchymal tissue to bone and forms the flat bones of the skull,...
Systemic factors that regulate the behaviour of chondrocytes in growth cartilage include growth hormone and thyroid hormone, and the local secreted factors include Indian hedgehog, parathyroid hormone-related peptide, fibroblast growth factors and components of the cartilage extracellular matrix. Transcription...
Corin is a protease that activates atrial natriuretic peptide (ANP), a hormone in cardiovascular homeostasis. Structurally, ANP is similar to C-type natriuretic peptide (CNP) crucial in bone development. Here, we examine the role of corin and ANP in chondrocyte differentiation and bone formation....
Some bones of the body are constituted by cartilaginous supports in which growth is produced both with the ossification process that extends from the center of the bone towards its borders in a process so called endochondral ossification. In this period of bone tissue morphogenesis the factors contr...
Progression of endochondral ossification in this tissue beyond the stage of hypertrophic cartilage appears to be associated with the expression of alkaline phosphatase activity. Costal chondrocytes in culture are stimulated by parathyroid hormone in a PTH/PTHrP receptor-mediated manner to express the fully...
Extraskeletal ossifications occur in the subcutisand in skeletal muscles associated with the affected long bones. Plasma calcium, phosphate and parathyroid hormone are normal.Skin 展开 DOI: 10.1007/s00441-007-0491-6 被引量: 21 年份: 2007 ...
Differential responses to parathyroid hormone-related protein (PTHrP) deficiency in the various craniofacial cartilages PTHrP null mutant mice exhibit skeletal abnormalities both in the craniofacial region and limbs. In the growth plate cartilage of the null mutant, a dimini... M Ishii-Suzuki,N Suda...