Osmotic Stress Triggers Phase Separation - ScienceDirectIn this issue of Molecular Cell, Jalihal et al. (2020) show that cell volume changes upon osmotic stress result in rapid and reversible condensation of numerous multivalent proteins.doi:10.1016/j.molcel.2020.09.001Sumit Majumder...
Cells are under threat of osmotic perturbation; cell volume maintenance is critical in cerebral edema, inflammation and aging, in which prominent changes in intracellular or extracellular osmolality emerge. After osmotic stress-enforced cell swelling or
restore cell volume and ion concentrations.In a recent study published in Cell,Boyd-Shiwarski et al.identify WNK1,a known homeostatic regulator of cell volume,as a molecular crowding sensor,and demonstrate how WNK1 contributes to cell volume recovery through cell shrinkage-dependent phase separation...
C-terminally Encoded Peptides CEPD: CEP Downstream CHO: Chinese Hamster Ovary Cl: Chloride CLE25: CLAVATA3/EMBRYO-SURROUNDING REGION- related25 CrRLK: Catharanthus roseus RLK1-Like kinases CSC1: Calcium-permeable Stress-gated cation Channel 1 CYCD: Cyclin D DCP1A: mRNA-Decapping enz...
Phospho-YAP is retained in the cytoplasm, where it is immediately degraded by proteasomes [41–45]. When the Hippo pathway is inactivated by low cell density or formation of actin stress fibers, YAP is not phosphorylated due to LATS inhibition. Consequently, YAP is translocated from the ...
various natural salt-lake brines, achieving a power density of 25.9 W m−2. This work triggers the hopes for practical blue energy conversion using advanced nanoarchitecture. Similar content being viewed by others All-natural 2D nanofluidics as highly-efficient osmotic energy generators...
It appears as if the cell is able to remember the stress history that is longer than the timescale of signal transduction. This is termed the long-term stress memory. Our experimental data verify this. Like S. cerevisiae, C. albicans mimimizes glycerol efflux during adaptation to hyper...
Clinton A. Taylorgrid.267313.20000 0000 9482 7121Department of PharmacologyUT Southwestern Medical Center Dallas TX USAMelanie H. Cobbgrid.267313.20000 0000 9482 7121Department of PharmacologyUT Southwestern Medical Center Dallas TX USASpringer Nature SingaporeCell Research...
Cells recognize osmotic stress through liquid-liquid phase separation lubricated with poly(ADP-ribose)doi:10.1101/2020.04.20.049759Kengo WatanabeKazuhiro MorishitaXiangyu ZhouShigeru ShiizakiYasuo UchiyamaMasato KoikeIsao NaguroHidenori IchijoCold Spring Harbor Laboratory...
and the Rg parent strain, in these cases, RbmA is present and it connects the cells to one another38. We suggest that RbmA creates a dense scaffold of cells to which the EPS adheres. This stiff cell-based scaffold strongly restricts the expansion of the EPS in the Rg and Δbap1Δr...