Maleczka R E,Shi F,Holmes D,et al.C-Hactivation/borylation/oxidation:a one-pot unified route to meta-substituted phenols bearing ortho-/para-directing groups. Journal of the American Chemical Society . 2003R.E. Maleczka, Jr, F. Shi, D. Holmes and M.R. Smith III, C-H Activation/...
Specific example: nitration of trifluoromethylbenzene gives themetaproduct in about 90% yield. (Compare that to the case of anisole, above, where nitration resulted in a <5% yield of themetaproduct. ) 3. How Well Do “ortho-, para” And “meta“- Directors Correlate With “...
3a, electronic and steric effects of the substituent on the aryl ring were investigated with primary benzylic silanes 1b‒1g (para-), 1h‒1j (meta-), 1k‒1m (ortho-). For the prototype reaction, this ortho-selective borylation process afforded 3a and 3a’ in 73% combined yield after...
ChemInform Abstract: PHOTOELECTRON SPECTRA OF ORTHO- AND META-SUBSTITUTED BENZONORBORNADIENES. RELATIONSHIPS TO REGIOSELECTIVITIES I... C−H Activation/Borylation/Oxidation: A One-Pot Unified Route To Meta-Substituted Phenols Bearing Ortho-/Para-Directing Groups ...
Xu J,Nareshkumar Jain,Zhihua Sui.Halogen–magnesium exchange of m-and p-iodo or bromo-arenes bearing ortho-directing groups through ate complexes. Tetrahedron Letters . 2004Halogen-magnesium exchange of m- and p-iodo orbromo-arenes bearing ortho-directing groups through atecomplexes. Jiayi Xu,et...
Starting materials with substituents either at the ortho-, meta-, or para- position of the hydroxyl group have been extensively evaluated, respectively. Generally, the electronic properties of substitution (either electron-donating or -withdrawing group) on the aromatic ring played a small role to ...
The directing effect of a substituent attached to an aromatic ring is predicted from its ability to donate or accept electrons from the aromatic ring through resonance. There are two kinds of directing substituents: (1) ortho-and para-director and (2) meta-director. ...
In ozone-mediated nitration of toluene, anisole and chlorobenzene with nitrogen dioxide, the initial products have been found to be composed mainly of the meta-nitro derivatives, but the isomer distributions are rapidly replaced by the ortho-para isomers as the reaction proceeds, sugesting the opera...
Halogen-magnesium exchange of m- and p-iodo orbromo-arenes bearing ortho-directing groups through atecomplexes. Jiayi Xu,et al.Tetrahedron Letters,Vol.45 . 2004Xu J,Nareshkumar Jain,Zhihua Sui.Halogen–magnesium exchange of m-and p-iodo or bromo-arenes bearing ortho-directing groups through ...
Meta- and Para-Difunctionalization of Arenes via an Ortho-Magnesiation and a Subsequent Sulfoxide-Magnesium Exchangemetalationortho-magnesiationsulfoxide-magnesium exchangepolyfunctional Grignard reagentsHighly functionalized 1,2,4-trisubstituted arenes can be prepared on large scale by a two-step Sequence, ...