Oxygenated phenols are mono-formylated using a mixture of paraformaldehyde, MgCl2, and Et3N in THF. In all cases but one, only one regioisomer of the salicylaldehyde is obtained in good to high yield.Formylation of aromatic compounds is an important reaction in synthetic organic chemistry, and ...
Trond Vidar Hansen.Ortho-formylation of phenols; Preparation of 3-bromosalicylaldeh-yde. Organic Synthesis . 2005Hansen TV., Skattebol L. (2005). Ortho-formylation of phenols; preparation of 3- bromosalicylaldehyde. Organic Syntheses 82: 64-68....
Trond Vidar HansenDep. Pharm. Chem., Sch. Pharm., Univ. Oslo, N-0316 Oslo, NorwayJohn Wiley & Sons, Ltd.ChemInformAkselsen, O.; Skattebol, L.; Hansen, T. V. ortho-Formylation of oxygenated phenols. Tetrahedron Lett. 2009, 50, 6339-6341.O. W. Akselsen, L. Skattebol and T. V...