Biochemistry Discovery of novel inhibitors of ornithine decarboxylase in Trypanosoma brucei| Development and application of a targeted high-throughput screening program UNIVERSITY OF CALIFORNIASAN FRANCISCO R. Kiplin Guy SmithsonDavid CHuman African Trypanosomiasis (HAT), caused by the eukaryotic parasite is...
X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine. X-ray structure of ornithine decarboxylase from Trypanosoma brucei: the native structure and the structure in complex with alpha-difluoromethylornithine...
Interestingly, there is a major difference in turnover rate between ornithine decarboxylases (ODCs) from various trypanosomatids. ODCs from Trypanosoma brucei and Leishmania donovani are both stable proteins, whereas ODC from Crithidia fasciculata is a metabolically unstable protein in the parasite. C....
7.10.2.2.1 Ornithine decarboxylase ODC is the most thoroughly studied PLP-dependent decarboxylase and its reaction mechanism can be considered the prototype for basic amino acid decarboxylases.52,53 ODC catalyzes the rate-limiting step in the biosynthesis of polyamines,57 that is, the decarboxylation...
Ornithine decarboxylase (ODC) is a key enzyme in the polyamine synthesis pathway in African trypanosomes. We report here the characterization of an ODC null bloodstream form Trypanosoma brucei brucei mutant, created by replacing the ODC gene with antibiotic resistant marker genes through transfection ...
Difluoromethylornithine, a Decarboxylase 1 Inhibitor, Suppresses Hepatitis B Virus Replication by Reducing HBc Protein Levels.| Mao, B., et al. 2020. Front Cell Infect Microbiol. 10: 158. PMID: 32373551 Inhibition of Polyamine Biosynthesis Using Difluoromethylornithine Acts as a Potent Immune Modu...
Ornithine decarboxylase (ODC) is a ubiquitous enzyme that is conserved in all species from bacteria to humans. Mammalian ODC is degraded by the proteasome in a ubiquitin-independent manner by direct binding to the antizyme (AZ). In contrast, Trypanosoma brucei ODC has a low binding affinity towa...
New insights into the pro-oxidant mechanism of dehydroleucodine on Trypanosoma cruzi Article Open access 14 August 2024 Structural and functional analysis of the Francisella lysine decarboxylase as a key actor in oxidative stress resistance Article Open access 13 January 2021 Introduction Intestinal...
DifluoromethylornithineCAS号:66640-93-5纯度:≥98% 分子量:236.65保存温度:-20°C产品介绍:Difluoromethylornithine (DFMO) exhibits anti-parasitic, anti-angiogenic, anti-metastatic, anticancer chemotherapeutic, and chemopreventive activities. DFMO inhibits ornithine decarboxylase, suppressing polyamine and thymidi...
L-Eflornithine (L-DFMO) 是 Eflornithine 的对映异构体。L-Eflornithine 是一种不可逆的鸟氨酸脱羧酶 (ornithine decarboxylase, ODC) 抑制剂,KD为 1.3±0.3 μM,Kinact为 0.15±0.03 min-1。 L-EflornithineChemical Structure CAS No. :66640-93-5 ...