Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts. By
lean Six Sigmaqualityquality movementquality controlquality management systemsSix Sigmastatistical quality controltotal quality managementThe pursuit of quality is an age-old endeavour that dates back to the beginning of civilization. Human beings have always encountered problems pertaining to quality, ...
highlighting the subjectivity of the perceptual evaluations, the averaging process reveals clear structure that aligns with the Western discrete scale system, as well as traditional hierarchies of consonance and dissonance. In
In the history of Lean, other concepts have been added. For example, the six-sigma, to form the "Lean Six-sigma".Lean, originally designed for production, has developed in several other environments, including: The "Lean office" or "Lean service", which deploys the principles of Lean in...
The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey—a jawl
The respondent is down in the weeds with details about his SixSigma project and the computer systems utilized in the project. It is difficult to evaluate the value of this idea without knowing more about the specific project and computer systems. One of the two judges gave the idea a score...
Most SLBRs of the first major branch of the tree (blue in Fig. 2) are broadly-selective and recognize two or more related tri-, tetra-, or hexasaccharides (see examples in Fig. 1). However, sequence similarly does not clearly predict the preferred glycan5,8,19,23. In contrast, ...
of Animal Science, University of Minnesota, St Paul, MN, USA In this study, we show how Y-specific interspersed multilocus microsatellites, which are loci that yield several amplified bands differing in size from the same male individual and PCR reaction, are a powerful source of information ...
do everything — it is part of a growing family of telescopes that must work together to study cosmic objects across diverse wavelengths of light. SPHEREx will survey the entire sky every six months using 96 different color bands, “far exceeding the color resolution of previous a...
It was also a factor that the Sigma-7 suffered a bit of schedule slippage. Yes, this actually happened despite firm assurances from SDS that no such thing was possible. SDS had even published several ads in trade magazines touting their forthcoming system as "the best timesharing system not...