Extrachromosomal DNA (ecDNA) is a major contributor to treatment resistance and poor outcome for patients with cancer1,2. Here we examine the diversity of ecDNA elements across cancer, revealing the associated tissue, genetic and mutational contexts. By
lean Six Sigmaqualityquality movementquality controlquality management systemsSix Sigmastatistical quality controltotal quality managementThe pursuit of quality is an age-old endeavour that dates back to the beginning of civilization. Human beings have always encountered problems pertaining to quality, ...
cerevisiae (herein referred to as ScORC) and is composed of six distinct subunits (Orc1–6) that bind in a sequence-specific manner to replication origins.38 In some yeast, but not all, origins of DNA replication correspond to genetic elements called autonomously replicating sequences (ARSs) ...
In the history of Lean, other concepts have been added. For example, the six-sigma, to form the "Lean Six-sigma".Lean, originally designed for production, has developed in several other environments, including: The "Lean office" or "Lean service", which deploys the principles of Lean in...
The phenomenon of musical consonance is an essential feature in diverse musical styles. The traditional belief, supported by centuries of Western music theory and psychological studies, is that consonance derives from simple (harmonic) frequency ratios b
The vertebrate brain emerged more than ~500 million years ago in common evolutionary ancestors. To systematically trace its cellular and molecular origins, we established a spatially resolved cell type atlas of the entire brain of the sea lamprey—a jawl
A precalibrated amount of DNase I (Sigma) was added in a volume of 0.01 ml for 1 min at room temperature. The reaction was stopped by precipitation in a mixture of ethanol, 0.3 m sodium acetate, and 1 μg of linear acrylamide. The precipitate was washed with 70% ethanol, dried, and...
The respondent is down in the weeds with details about his SixSigma project and the computer systems utilized in the project. It is difficult to evaluate the value of this idea without knowing more about the specific project and computer systems. One of the two judges gave the idea a score...
Most SLBRs of the first major branch of the tree (blue in Fig. 2) are broadly-selective and recognize two or more related tri-, tetra-, or hexasaccharides (see examples in Fig. 1). However, sequence similarly does not clearly predict the preferred glycan5,8,19,23. In contrast, ...
of Animal Science, University of Minnesota, St Paul, MN, USA In this study, we show how Y-specific interspersed multilocus microsatellites, which are loci that yield several amplified bands differing in size from the same male individual and PCR reaction, are a powerful source of information ...